@article{782930a6089c42dca67fb2c47a731cb1,
title = "Lung cancer signatures in plasma based on proteome profiling of mouse tumor models",
abstract = "We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.",
author = "Ayumu Taguchi and Katerina Politi and Pitteri, {Sharon J.} and Lockwood, {William W.} and Fa{\c c}a, {Vitor M.} and Karen Kelly-Spratt and Wong, {Chee Hong} and Qing Zhang and Alice Chin and Park, {Kwon Sik} and Gary Goodman and Gazdar, {Adi F.} and Julien Sage and Dinulescu, {Daniela M.} and Raju Kucherlapati and DePinho, {Ronald A.} and Kemp, {Christopher J.} and Varmus, {Harold E.} and Hanash, {Samir M.}",
note = "Funding Information: Funding support was provided by the National Cancer Institute's Mouse Models of Human Cancer program; the Canary, Labrecque, and Uniting Against Lung Cancer Foundations; and the Department of Defense (DOD) Congressionally Mandated Lung Cancer Research program. K.S.P. is a Parker B. Francis Fellow. D.M.D. is supported by the DOD (grant no. W81XWH-10-1-0263) and by the Burroughs Wellcome, V Foundation, Mary Kay Ash, and Rivkin Foundations. The authors declare no competing financial interests. ",
year = "2011",
month = sep,
doi = "10.1016/j.ccr.2011.08.007",
language = "English (US)",
volume = "20",
pages = "289--299",
journal = "Cancer cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",
}