Lymphokine-activated killer cell activity. Characteristics of effector cells and their progenitors in blood and spleen

Ronald B. Herberman; John Hiserodt; Nicola Vujanovic; Charles Balch; Eva Lotzova; Reinder Bolhuis; Sidney Golub; Lewis L. Lanier; Joseph H. Phillips; Carlo Riccardi; Jerome Ritz; Angela Santoni; Reinholdt E. Schmidt; Atsushi Uchida

doi:10.1016/0167-5699(87)90035-1

Lymphokine-activated killer cell activity. Characteristics of effector cells and their progenitors in blood and spleen

Ronald B. Herberman, John Hiserodt, Nicola Vujanovic, Charles Balch, Eva Lotzova, Reinder Bolhuis, Sidney Golub, Lewis L. Lanier, Joseph H. Phillips, Carlo Riccardi, Jerome Ritz, Angela Santoni, Reinholdt E. Schmidt, Atsushi Uchida

Surgical Oncology

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237 Scopus citations

Abstract

Leukocytes in blood and spleen can be activated by interleukin 2 (IL-2) to become cytotoxic to certain tumor cell lines in vitro. Recent evidence suggests that such lymphokine-activated killer (LAK) cells can bring about the regression of solid tumors in animals and patients, under certain circumstances. Here, Ronald Herberman and colleagues from eight international laboratories, review what is known of the characteristics of LAK cell activity and conclude that most of it can be attributed to natural killer cells stimulated by IL-2.

Original language	English (US)
Pages (from-to)	178-181
Number of pages	4
Journal	Immunology Today
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/0167-5699(87)90035-1
State	Published - 1987

ASJC Scopus subject areas

Immunology

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Herberman, R. B., Hiserodt, J., Vujanovic, N., Balch, C., Lotzova, E., Bolhuis, R., Golub, S., Lanier, L. L., Phillips, J. H., Riccardi, C., Ritz, J., Santoni, A., Schmidt, R. E., & Uchida, A. (1987). Lymphokine-activated killer cell activity. Characteristics of effector cells and their progenitors in blood and spleen. Immunology Today, 8(6), 178-181. https://doi.org/10.1016/0167-5699(87)90035-1

Herberman, RB, Hiserodt, J, Vujanovic, N, Balch, C, Lotzova, E, Bolhuis, R, Golub, S, Lanier, LL, Phillips, JH, Riccardi, C, Ritz, J, Santoni, A, Schmidt, RE & Uchida, A 1987, 'Lymphokine-activated killer cell activity. Characteristics of effector cells and their progenitors in blood and spleen', Immunology Today, vol. 8, no. 6, pp. 178-181. https://doi.org/10.1016/0167-5699(87)90035-1

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AU - Herberman, Ronald B.

AU - Hiserodt, John

AU - Vujanovic, Nicola

AU - Balch, Charles

AU - Lotzova, Eva

AU - Bolhuis, Reinder

AU - Golub, Sidney

AU - Lanier, Lewis L.

AU - Phillips, Joseph H.

AU - Riccardi, Carlo

AU - Ritz, Jerome

AU - Santoni, Angela

AU - Schmidt, Reinholdt E.

AU - Uchida, Atsushi

PY - 1987

Y1 - 1987

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AB - Leukocytes in blood and spleen can be activated by interleukin 2 (IL-2) to become cytotoxic to certain tumor cell lines in vitro. Recent evidence suggests that such lymphokine-activated killer (LAK) cells can bring about the regression of solid tumors in animals and patients, under certain circumstances. Here, Ronald Herberman and colleagues from eight international laboratories, review what is known of the characteristics of LAK cell activity and conclude that most of it can be attributed to natural killer cells stimulated by IL-2.

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Lymphokine-activated killer cell activity. Characteristics of effector cells and their progenitors in blood and spleen

Abstract

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