TY - JOUR
T1 - Lymphoplasmacytic lymphoma and Waldenström macroglobulinaemia
T2 - clinicopathological features and differential diagnosis
AU - Wang, Wei
AU - Lin, Pei
N1 - Publisher Copyright:
© 2019 Royal College of Pathologists of Australasia
PY - 2020/1
Y1 - 2020/1
N2 - Lymphoplasmacytic lymphoma (LPL) represents a distinct type of mature B-cell lymphoma with a substantial subset of cases being associated with Waldenström macroglobulinaemia (WM), defined as primarily bone marrow involvement and the presence of an IgM monoclonal paraprotein. MYD88 L265P mutation, although not specific, is present in the vast majority (>90%) of LPL cases and sheds light on the potential pathogenesis of this disease. This review offers an overview of current knowledge on the pathogenesis, clinical presentations, histological features and immunophenotype of LPL and WM. In addition, the differential diagnosis of LPL and WM from other mature B cell neoplasms is highlighted with a focus on distinction from marginal zone lymphoma and plasma cell neoplasms.
AB - Lymphoplasmacytic lymphoma (LPL) represents a distinct type of mature B-cell lymphoma with a substantial subset of cases being associated with Waldenström macroglobulinaemia (WM), defined as primarily bone marrow involvement and the presence of an IgM monoclonal paraprotein. MYD88 L265P mutation, although not specific, is present in the vast majority (>90%) of LPL cases and sheds light on the potential pathogenesis of this disease. This review offers an overview of current knowledge on the pathogenesis, clinical presentations, histological features and immunophenotype of LPL and WM. In addition, the differential diagnosis of LPL and WM from other mature B cell neoplasms is highlighted with a focus on distinction from marginal zone lymphoma and plasma cell neoplasms.
KW - Lymphoplasmacytic lymphoma
KW - Waldenström macroglobulinaemia
KW - diagnosis
KW - differential diagnosis
KW - pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=85075852710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075852710&partnerID=8YFLogxK
U2 - 10.1016/j.pathol.2019.09.009
DO - 10.1016/j.pathol.2019.09.009
M3 - Review article
C2 - 31767130
AN - SCOPUS:85075852710
SN - 0031-3025
VL - 52
SP - 6
EP - 14
JO - Pathology
JF - Pathology
IS - 1
ER -