TY - JOUR
T1 - Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia associated with Hodgkin disease
T2 - A report of two cases
AU - Rosales, Cecilia M.
AU - Lin, Pei
AU - Mansoor, Adnan
AU - Bueso-Ramos, Carlos
AU - Medeiros, L. Jeffrey
PY - 2001/7
Y1 - 2001/7
N2 - Although the clinical course of lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM) is usually indolent, high-grade non-Hodgkin lymphoma may develop in a small subset of patients. We have not found any patients with LPL/WM associated with Hodgkin disease (HD) described in the literature, prompting us to report 2 cases. In case 1, the patient had LPL/WM involving bone marrow diagnosed 1 week before left supraclavicular lymph node biopsy revealed LPL/WM and classical HD. In case 2, the patient had a 15-year history of LPL/WM before classical HD developed involving bone marrow, liver, and lymph node. Both cases were positive for IgM, monotypic immunoglobulin light chain, and B-cell antigens and were CD3-. The neoplastic Hodgkin cells were CD15+, CD20+ (case 1), CD30+, CD3-, and CD45- and were negative for Epstein-Barr virus RNA. Both patients were treated with chemotherapy for HD. In case 1, clinical response was excellent with no histologic evidence of HD in subsequent biopsy specimens. In case 2, HD was progressive at last follow-up, despite therapy. Patients with LPL/WM, similar to patients with other types of low-grade B-cell lymphoma, can develop HD that may respond to chemotherapy.
AB - Although the clinical course of lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM) is usually indolent, high-grade non-Hodgkin lymphoma may develop in a small subset of patients. We have not found any patients with LPL/WM associated with Hodgkin disease (HD) described in the literature, prompting us to report 2 cases. In case 1, the patient had LPL/WM involving bone marrow diagnosed 1 week before left supraclavicular lymph node biopsy revealed LPL/WM and classical HD. In case 2, the patient had a 15-year history of LPL/WM before classical HD developed involving bone marrow, liver, and lymph node. Both cases were positive for IgM, monotypic immunoglobulin light chain, and B-cell antigens and were CD3-. The neoplastic Hodgkin cells were CD15+, CD20+ (case 1), CD30+, CD3-, and CD45- and were negative for Epstein-Barr virus RNA. Both patients were treated with chemotherapy for HD. In case 1, clinical response was excellent with no histologic evidence of HD in subsequent biopsy specimens. In case 2, HD was progressive at last follow-up, despite therapy. Patients with LPL/WM, similar to patients with other types of low-grade B-cell lymphoma, can develop HD that may respond to chemotherapy.
KW - Bone marrow
KW - Hodgkin disease
KW - Immunohistochemistry
KW - Lymph node
KW - Lymphoplasmacytic lymphoma
KW - Waldenström macroglobulinemia
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U2 - 10.1309/9DBY-FBUG-Y10A-AAXT
DO - 10.1309/9DBY-FBUG-Y10A-AAXT
M3 - Article
C2 - 11447749
AN - SCOPUS:0034954296
SN - 0002-9173
VL - 116
SP - 34
EP - 40
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 1
ER -