M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein

Fang Zhang; Douglas L. Hogue; Lin Liu; Cynthia L. Fisher; David Hui; Sarah Childs; Victor Ling

doi:10.1016/S0014-5793(00)01823-8

M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein

Fang Zhang, Douglas L. Hogue, Lin Liu, Cynthia L. Fisher, David Hui, Sarah Childs, Victor Ling

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 (Allikmets et al. (1995) Mamm. Genome 6, 111-117). The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non-expressed pseudogene also exists at chromosome 15q13-14. The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.

Original language	English (US)
Pages (from-to)	89-94
Number of pages	6
Journal	FEBS Letters
Volume	478
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(00)01823-8
State	Published - Jul 28 2000
Externally published	Yes

Keywords

ATP-binding cassette protein
Mitochondrion
Pseudogene
Signal sequence

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(00)01823-8

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title = "M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein",

abstract = "We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 (Allikmets et al. (1995) Mamm. Genome 6, 111-117). The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non-expressed pseudogene also exists at chromosome 15q13-14. The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.",

keywords = "ATP-binding cassette protein, Mitochondrion, Pseudogene, Signal sequence",

author = "Fang Zhang and Hogue, {Douglas L.} and Lin Liu and Fisher, {Cynthia L.} and David Hui and Sarah Childs and Victor Ling",

note = "Funding Information: This work was supported by grants from the National Cancer Institute of Canada, an Alberta Heritage Foundation for Medical Research Fellowship (to D.L.H.), a Medical Research Council of Canada Studentship (to C.L.F.), a National Cancer Institute of Canada Steve Fonyo Fellowship (to S.C.) and a Canadian Breast Cancer Foundation Studentship (to D.H.). The authors thank Dr. Jonathan A. Sheps for phylogenetic analysis. ",

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doi = "10.1016/S0014-5793(00)01823-8",

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T1 - M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein

AU - Zhang, Fang

AU - Hogue, Douglas L.

AU - Liu, Lin

AU - Fisher, Cynthia L.

AU - Hui, David

AU - Childs, Sarah

AU - Ling, Victor

N1 - Funding Information: This work was supported by grants from the National Cancer Institute of Canada, an Alberta Heritage Foundation for Medical Research Fellowship (to D.L.H.), a Medical Research Council of Canada Studentship (to C.L.F.), a National Cancer Institute of Canada Steve Fonyo Fellowship (to S.C.) and a Canadian Breast Cancer Foundation Studentship (to D.H.). The authors thank Dr. Jonathan A. Sheps for phylogenetic analysis.

PY - 2000/7/28

Y1 - 2000/7/28

N2 - We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 (Allikmets et al. (1995) Mamm. Genome 6, 111-117). The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non-expressed pseudogene also exists at chromosome 15q13-14. The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.

AB - We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 (Allikmets et al. (1995) Mamm. Genome 6, 111-117). The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non-expressed pseudogene also exists at chromosome 15q13-14. The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.

KW - ATP-binding cassette protein

KW - Mitochondrion

KW - Pseudogene

KW - Signal sequence

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AN - SCOPUS:0034726103

SN - 0014-5793

VL - 478

SP - 89

EP - 94

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein

Abstract

Keywords

ASJC Scopus subject areas

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