Macrophage chemoattractants secreted by cancer cells: Sculptors of the tumor microenvironment and another crucial piece of the cancer secretome as a therapeutic target

Nese Unver

doi:10.1016/j.cytogfr.2019.05.010

Macrophage chemoattractants secreted by cancer cells: Sculptors of the tumor microenvironment and another crucial piece of the cancer secretome as a therapeutic target

Nese Unver

Clinical Cancer Prevention

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Beyond their essential role in leukocyte homing in the context of inflammation, chemokines orchestrate the host response to cancer progression. Chemokines are key accelerators in the amplification of inflammatory signals and metastasis in the distal zone of tumors, indicating possible immune editing of tumor cells in the microenvironment. This review summarizes the main macrophage-attracting chemokines secreted from cancer cells and how these mediators can be targeted to improve cancer immunotherapy in multiple cancer types.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	Cytokine and Growth Factor Reviews
Volume	50
DOIs	https://doi.org/10.1016/j.cytogfr.2019.05.010
State	Published - Dec 2019

Keywords

CCL chemokines
CXCL chemokines
Chemoattractant
Chemokines
Immunotherapy
Macrophage
Tumor-associated macrophages

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cytogfr.2019.05.010

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title = "Macrophage chemoattractants secreted by cancer cells: Sculptors of the tumor microenvironment and another crucial piece of the cancer secretome as a therapeutic target",

abstract = "Beyond their essential role in leukocyte homing in the context of inflammation, chemokines orchestrate the host response to cancer progression. Chemokines are key accelerators in the amplification of inflammatory signals and metastasis in the distal zone of tumors, indicating possible immune editing of tumor cells in the microenvironment. This review summarizes the main macrophage-attracting chemokines secreted from cancer cells and how these mediators can be targeted to improve cancer immunotherapy in multiple cancer types.",

keywords = "CCL chemokines, CXCL chemokines, Chemoattractant, Chemokines, Immunotherapy, Macrophage, Tumor-associated macrophages",

author = "Nese Unver",

year = "2019",

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doi = "10.1016/j.cytogfr.2019.05.010",

language = "English (US)",

volume = "50",

pages = "13--18",

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T1 - Macrophage chemoattractants secreted by cancer cells

T2 - Sculptors of the tumor microenvironment and another crucial piece of the cancer secretome as a therapeutic target

AU - Unver, Nese

PY - 2019/12

Y1 - 2019/12

N2 - Beyond their essential role in leukocyte homing in the context of inflammation, chemokines orchestrate the host response to cancer progression. Chemokines are key accelerators in the amplification of inflammatory signals and metastasis in the distal zone of tumors, indicating possible immune editing of tumor cells in the microenvironment. This review summarizes the main macrophage-attracting chemokines secreted from cancer cells and how these mediators can be targeted to improve cancer immunotherapy in multiple cancer types.

AB - Beyond their essential role in leukocyte homing in the context of inflammation, chemokines orchestrate the host response to cancer progression. Chemokines are key accelerators in the amplification of inflammatory signals and metastasis in the distal zone of tumors, indicating possible immune editing of tumor cells in the microenvironment. This review summarizes the main macrophage-attracting chemokines secreted from cancer cells and how these mediators can be targeted to improve cancer immunotherapy in multiple cancer types.

KW - CCL chemokines

KW - CXCL chemokines

KW - Chemoattractant

KW - Chemokines

KW - Immunotherapy

KW - Macrophage

KW - Tumor-associated macrophages

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DO - 10.1016/j.cytogfr.2019.05.010

M3 - Review article

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AN - SCOPUS:85066114039

SN - 1359-6101

VL - 50

SP - 13

EP - 18

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

ER -

Macrophage chemoattractants secreted by cancer cells: Sculptors of the tumor microenvironment and another crucial piece of the cancer secretome as a therapeutic target

Abstract

Keywords

ASJC Scopus subject areas

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