TY - JOUR
T1 - Magnetic resonance imaging captures the biology of ductal carcinoma in situ
AU - Esserman, Laura J.
AU - Kumar, Anjali S.
AU - Herrera, Alex F.
AU - Leung, Jessica
AU - Au, Alfred
AU - Chen, Yunn Yi
AU - Moore, Dan H.
AU - Chen, Daniel F.
AU - Hellawell, Jennifer
AU - Wolverton, Dulcy
AU - Hwang, E. Shelley
AU - Hylton, Nola M.
PY - 2006/10/1
Y1 - 2006/10/1
N2 - Purpose: Magnetic resonance imaging (MRI) is an important tool for characterizing invasive breast cancer but has proven to be more challenging in the setting of ductal carcinoma in situ (DCIS). We investigated whether MRI features of DCIS reflect differences in biology and pathology. Patients and Methods: Forty five of 100 patients with biopsy-proven DCIS who underwent MRI and had sufficient tissue to be characterized by pathologic (nuclear grade, presence of comedo necrosis, size, and density of disease) and immunohistochemical (IHC) findings (proliferation, Ki67; angiogenesis, CD34; and inflammation, CD68). Pathology and MRI features (enhancement patterns, distribution, size, and density) were analyzed using pairwise and canonical correlations. Results: Histopathologic and IHC variables correlated with MRI features (r = 0.73). The correlation was largely due to size, density (by either MRI or pathology), and inflammation (P < .05). Most small focal masses were estrogen receptor-positive. MRI enhancement patterns that were clumped were more likely than heterogeneous patterns to be high-grade lesions. Homogenous lesions were large, high grade, and rich in macrophages. Presence of comedo necrosis and size could be distinguished on MRI (P < .05). MRI was most likely to over-represent the size of less dense, diffuse DCIS lesions. Conclusion: The heterogeneous presentation of DCIS on MRI reflects underlying histopathologic differences.
AB - Purpose: Magnetic resonance imaging (MRI) is an important tool for characterizing invasive breast cancer but has proven to be more challenging in the setting of ductal carcinoma in situ (DCIS). We investigated whether MRI features of DCIS reflect differences in biology and pathology. Patients and Methods: Forty five of 100 patients with biopsy-proven DCIS who underwent MRI and had sufficient tissue to be characterized by pathologic (nuclear grade, presence of comedo necrosis, size, and density of disease) and immunohistochemical (IHC) findings (proliferation, Ki67; angiogenesis, CD34; and inflammation, CD68). Pathology and MRI features (enhancement patterns, distribution, size, and density) were analyzed using pairwise and canonical correlations. Results: Histopathologic and IHC variables correlated with MRI features (r = 0.73). The correlation was largely due to size, density (by either MRI or pathology), and inflammation (P < .05). Most small focal masses were estrogen receptor-positive. MRI enhancement patterns that were clumped were more likely than heterogeneous patterns to be high-grade lesions. Homogenous lesions were large, high grade, and rich in macrophages. Presence of comedo necrosis and size could be distinguished on MRI (P < .05). MRI was most likely to over-represent the size of less dense, diffuse DCIS lesions. Conclusion: The heterogeneous presentation of DCIS on MRI reflects underlying histopathologic differences.
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U2 - 10.1200/JCO.2005.04.5518
DO - 10.1200/JCO.2005.04.5518
M3 - Article
C2 - 17008702
AN - SCOPUS:33750587397
SN - 0732-183X
VL - 24
SP - 4603
EP - 4610
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 28
ER -