TY - GEN
T1 - Magnetically-responsive nanoparticles for vectored delivery of cancer therapeutics
AU - Klostergaard, Jim
AU - Bankson, James
AU - Woodward, Wendy
AU - Gibson, Don
AU - Seeney, Charles
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - We propose that physical targeting of therapeutics to tumors using magnetically-responsive nanoparticles (MNPs) will enhance intratumoral drug levels compared to free drugs in an effort to overcome tumor resistance. We evaluated the feasibility of magnetic enhancement of tumor extravasation of systemically-administered MNPs in human xenografts implanted in the mammary fatpads of nude mice. Mice with orthotopic tumors were injected systemically with MNPs, with a focused magnetic field juxtaposed over the tumor. Magnetic resonance imaging and scanning electron microscopy both indicated successful tumor localization of MNPs. Next, MNPs were modified with poly-ethylene-glycol (PEG) and their clearance compared by estimating signal attenuation in liver due to iron accumulation. The results suggested that PEG substitution could retard the rate of MNP plasma clearance, which may allow greater magnetically-enhanced tumor localization. We propose that this technology is clinically scalable to many types of both superficial as well as some viscerable tumors with existing magnetic technology.
AB - We propose that physical targeting of therapeutics to tumors using magnetically-responsive nanoparticles (MNPs) will enhance intratumoral drug levels compared to free drugs in an effort to overcome tumor resistance. We evaluated the feasibility of magnetic enhancement of tumor extravasation of systemically-administered MNPs in human xenografts implanted in the mammary fatpads of nude mice. Mice with orthotopic tumors were injected systemically with MNPs, with a focused magnetic field juxtaposed over the tumor. Magnetic resonance imaging and scanning electron microscopy both indicated successful tumor localization of MNPs. Next, MNPs were modified with poly-ethylene-glycol (PEG) and their clearance compared by estimating signal attenuation in liver due to iron accumulation. The results suggested that PEG substitution could retard the rate of MNP plasma clearance, which may allow greater magnetically-enhanced tumor localization. We propose that this technology is clinically scalable to many types of both superficial as well as some viscerable tumors with existing magnetic technology.
KW - Magnetically responsive nanoparticles (MNPs)
KW - inflammatory breast cancer (IBC)
KW - magnetic resonance imaging (MRI)
KW - poly-ethyleneglycol (PEG)
KW - tumor localization/extravasation
UR - http://www.scopus.com/inward/record.url?scp=79251577082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79251577082&partnerID=8YFLogxK
U2 - 10.1063/1.3530042
DO - 10.1063/1.3530042
M3 - Conference contribution
AN - SCOPUS:79251577082
SN - 9780735408661
T3 - AIP Conference Proceedings
SP - 382
EP - 387
BT - 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
T2 - 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
Y2 - 25 May 2010 through 29 May 2010
ER -