Abstract
The systemic administration of doxorubicin (DXR) decreases the number of epithelial cells and leukocytes in the small intestine of mice. Oral administration of muramyl tripeptide phosphatidylethanolamine (MTP-PE) prevented both disruption of intestinal architecture, and a decrease in the number of macrophages, and it induced the expression of IL-6, G-CSF, GM-CSF, and TNF-α in the intestinal tissue. The data suggest that the oral administration of MTP-PE can prevent chemotherapy-induced toxicity to the intestinal mucosa and hence infections due to translocation of aerobic bacteria from the intestine to the blood.
Original language | English (US) |
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Pages (from-to) | 363-371 |
Number of pages | 9 |
Journal | Cancer Biotherapy and Radiopharmaceuticals |
Volume | 11 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1996 |
Keywords
- MTP-PE
- chemotherapy
- intestinal epithelium
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Pharmacology
- Cancer Research