MALAT1 protects dormant tumor cells from immune elimination

Zhibin Zhang; Judy Lieberman

doi:10.1038/s43018-023-00682-0

MALAT1 protects dormant tumor cells from immune elimination

Zhibin Zhang, Judy Lieberman

Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer cells seed distant tissues and remain dormant before re-entering the cell cycle to form metastases. How tumor dormancy is maintained and how cells exit dormancy is poorly understood. A study shows that the lncRNA MALAT1 reactivates dormant cancer cells by upregulating serpin protease inhibitors in tumor cells to evade CD8⁺ T cells.

Original language	English (US)
Pages (from-to)	218-220
Number of pages	3
Journal	Nature Cancer
Volume	5
Issue number	2
DOIs	https://doi.org/10.1038/s43018-023-00682-0
State	Published - Feb 2024

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/s43018-023-00682-0

Cite this

@article{f0a7748a33b44f1aae69b1feda6117e2,

title = "MALAT1 protects dormant tumor cells from immune elimination",

abstract = "Cancer cells seed distant tissues and remain dormant before re-entering the cell cycle to form metastases. How tumor dormancy is maintained and how cells exit dormancy is poorly understood. A study shows that the lncRNA MALAT1 reactivates dormant cancer cells by upregulating serpin protease inhibitors in tumor cells to evade CD8+ T cells.",

author = "Zhibin Zhang and Judy Lieberman",

note = "Publisher Copyright: {\textcopyright} Springer Nature America, Inc 2024.",

year = "2024",

month = feb,

doi = "10.1038/s43018-023-00682-0",

language = "English (US)",

volume = "5",

pages = "218--220",

journal = "Nature Cancer",

issn = "2662-1347",

publisher = "Nature Research",

number = "2",

}

TY - JOUR

T1 - MALAT1 protects dormant tumor cells from immune elimination

AU - Zhang, Zhibin

AU - Lieberman, Judy

N1 - Publisher Copyright: © Springer Nature America, Inc 2024.

PY - 2024/2

Y1 - 2024/2

N2 - Cancer cells seed distant tissues and remain dormant before re-entering the cell cycle to form metastases. How tumor dormancy is maintained and how cells exit dormancy is poorly understood. A study shows that the lncRNA MALAT1 reactivates dormant cancer cells by upregulating serpin protease inhibitors in tumor cells to evade CD8+ T cells.

AB - Cancer cells seed distant tissues and remain dormant before re-entering the cell cycle to form metastases. How tumor dormancy is maintained and how cells exit dormancy is poorly understood. A study shows that the lncRNA MALAT1 reactivates dormant cancer cells by upregulating serpin protease inhibitors in tumor cells to evade CD8+ T cells.

UR - http://www.scopus.com/inward/record.url?scp=85181907393&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85181907393&partnerID=8YFLogxK

U2 - 10.1038/s43018-023-00682-0

DO - 10.1038/s43018-023-00682-0

M3 - Article

C2 - 38195934

AN - SCOPUS:85181907393

SN - 2662-1347

VL - 5

SP - 218

EP - 220

JO - Nature Cancer

JF - Nature Cancer

IS - 2

ER -

MALAT1 protects dormant tumor cells from immune elimination

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this