TY - JOUR
T1 - Male Mammary Paget Disease
T2 - A Tale of 2 Contrasting Cases
AU - Roy, Madhuchhanda
AU - Teshome, Mediget
AU - Damodaran, Senthilkumar
AU - Sahin, Aysegul A.
AU - Khazai, Laila
AU - Arribas, Elsa
AU - Candelaria, Rosalind P.
AU - Scoggins, Marion E.
AU - Lane, Deanna L.
AU - Giordano, Sharon H.
AU - Albarracin, Constance T.
AU - Prieto, Victor G.
AU - Nagarajan, Priyadharsini
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Mammary Paget disease (MPD) comprises 1.45% all male breast cancers, compared with only 0.68% of all female breast cancers. Patients usually present in the fifth and sixth decades of life with ulceration, eczematous changes, discharge, bleeding, itching, and induration of the nipple and areola. Typically, there is a delay in definitive diagnosis and treatment from the onset of symptoms because most patients are initially treated for a rash. At the time of diagnosis, about half of the patients may have palpable breast mass, positive lymph nodes, or both. In this article, we present 2 cases of male MPD representing the extremes of clinical, radiologic, and histopathologic spectrum of the disease. One patient presented with a rash of the nipple of several months duration without an underlying lesion, whereas the other presented with sensitivity and pain of the nipple for 1 year and an underlying mass. Biopsies were diagnostic of MPD in both cases, and definitive surgery revealed an underlying ductal carcinoma in situ in the first case and an invasive ductal carcinoma in the second, highlighting the importance of early biopsy to initiate appropriate management.
AB - Mammary Paget disease (MPD) comprises 1.45% all male breast cancers, compared with only 0.68% of all female breast cancers. Patients usually present in the fifth and sixth decades of life with ulceration, eczematous changes, discharge, bleeding, itching, and induration of the nipple and areola. Typically, there is a delay in definitive diagnosis and treatment from the onset of symptoms because most patients are initially treated for a rash. At the time of diagnosis, about half of the patients may have palpable breast mass, positive lymph nodes, or both. In this article, we present 2 cases of male MPD representing the extremes of clinical, radiologic, and histopathologic spectrum of the disease. One patient presented with a rash of the nipple of several months duration without an underlying lesion, whereas the other presented with sensitivity and pain of the nipple for 1 year and an underlying mass. Biopsies were diagnostic of MPD in both cases, and definitive surgery revealed an underlying ductal carcinoma in situ in the first case and an invasive ductal carcinoma in the second, highlighting the importance of early biopsy to initiate appropriate management.
UR - http://www.scopus.com/inward/record.url?scp=85097574542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097574542&partnerID=8YFLogxK
U2 - 10.1097/DAD.0000000000001799
DO - 10.1097/DAD.0000000000001799
M3 - Article
C2 - 33289978
AN - SCOPUS:85097574542
SN - 0193-1091
VL - 42
SP - 981
EP - 985
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 12
ER -