Malignant melanoma arising in an ovarian carcinosarcoma: Case report and review of the literature

Andres A. Roma; Anais Malpica; Michael T. Deavers

doi:10.1097/PGP.0b013e3181f9eba5

Malignant melanoma arising in an ovarian carcinosarcoma: Case report and review of the literature

Andres A. Roma, Anais Malpica, Michael T. Deavers

Pathology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

A case of ovarian malignant mixed mullerian tumor (MMMT) with melanocytic differentiation is described. A 74-year-old woman presented with left lower quadrant pain. Pathologic examination of the left ovary revealed a MMMT, composed predominantly of serous carcinoma (90%) with a minor sarcoma component containing focal chondroid differentiation. There was also a single focus of malignant melanoma. Immunohistochemical studies showed that the latter was positive for S-100, HMB-45, and pan-melanoma cocktail, and was negative for synaptophysin and neuron-specific enolase. To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary.

Original language	English (US)
Pages (from-to)	158-162
Number of pages	5
Journal	International Journal of Gynecological Pathology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1097/PGP.0b013e3181f9eba5
State	Published - Mar 2011

Keywords

Carcinosarcoma
HMB-45
Melanoma
Melanotic neuroectodermal tumor of infancy
Ovary-Malignant mixed mullerian tumor
S-100

ASJC Scopus subject areas

Pathology and Forensic Medicine
Obstetrics and Gynecology

Access to Document

10.1097/PGP.0b013e3181f9eba5

Cite this

@article{bb12e0c9cd0e43ba9c9e1e0edbdc4cec,

title = "Malignant melanoma arising in an ovarian carcinosarcoma: Case report and review of the literature",

abstract = "A case of ovarian malignant mixed mullerian tumor (MMMT) with melanocytic differentiation is described. A 74-year-old woman presented with left lower quadrant pain. Pathologic examination of the left ovary revealed a MMMT, composed predominantly of serous carcinoma (90%) with a minor sarcoma component containing focal chondroid differentiation. There was also a single focus of malignant melanoma. Immunohistochemical studies showed that the latter was positive for S-100, HMB-45, and pan-melanoma cocktail, and was negative for synaptophysin and neuron-specific enolase. To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary.",

keywords = "Carcinosarcoma, HMB-45, Melanoma, Melanotic neuroectodermal tumor of infancy, Ovary-Malignant mixed mullerian tumor, S-100",

author = "Roma, {Andres A.} and Anais Malpica and Deavers, {Michael T.}",

year = "2011",

month = mar,

doi = "10.1097/PGP.0b013e3181f9eba5",

language = "English (US)",

volume = "30",

pages = "158--162",

journal = "International Journal of Gynecological Pathology",

issn = "0277-1691",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Malignant melanoma arising in an ovarian carcinosarcoma

T2 - Case report and review of the literature

AU - Roma, Andres A.

AU - Malpica, Anais

AU - Deavers, Michael T.

PY - 2011/3

Y1 - 2011/3

N2 - A case of ovarian malignant mixed mullerian tumor (MMMT) with melanocytic differentiation is described. A 74-year-old woman presented with left lower quadrant pain. Pathologic examination of the left ovary revealed a MMMT, composed predominantly of serous carcinoma (90%) with a minor sarcoma component containing focal chondroid differentiation. There was also a single focus of malignant melanoma. Immunohistochemical studies showed that the latter was positive for S-100, HMB-45, and pan-melanoma cocktail, and was negative for synaptophysin and neuron-specific enolase. To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary.

AB - A case of ovarian malignant mixed mullerian tumor (MMMT) with melanocytic differentiation is described. A 74-year-old woman presented with left lower quadrant pain. Pathologic examination of the left ovary revealed a MMMT, composed predominantly of serous carcinoma (90%) with a minor sarcoma component containing focal chondroid differentiation. There was also a single focus of malignant melanoma. Immunohistochemical studies showed that the latter was positive for S-100, HMB-45, and pan-melanoma cocktail, and was negative for synaptophysin and neuron-specific enolase. To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary.

KW - Carcinosarcoma

KW - HMB-45

KW - Melanoma

KW - Melanotic neuroectodermal tumor of infancy

KW - Ovary-Malignant mixed mullerian tumor

KW - S-100

UR - http://www.scopus.com/inward/record.url?scp=79951771300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951771300&partnerID=8YFLogxK

U2 - 10.1097/PGP.0b013e3181f9eba5

DO - 10.1097/PGP.0b013e3181f9eba5

M3 - Review article

C2 - 21293284

AN - SCOPUS:79951771300

SN - 0277-1691

VL - 30

SP - 158

EP - 162

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

IS - 2

ER -

Malignant melanoma arising in an ovarian carcinosarcoma: Case report and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this