TY - JOUR
T1 - Malignant melanoma
T2 - Relationship of the human leukocyte antigen class II gene DQB1*0301 to disease recurrence in American Joint Committee on Cancer Stage I or II
AU - Lee, Jeffrey E.
AU - Lu, Meisheng
AU - Mansfield, Paul F.
AU - Platsoucas, Chris D.
AU - Reveille, John D.
AU - Ross, Merrick I.
PY - 1996/8/15
Y1 - 1996/8/15
N2 - BACKGROUND. Melanoma patients who carry the human leukocyte antigen (HLA) Class II allele DQB1*0301 have an increased frequency of metastases at presentation compared with those lacking HLA-DQB1*0301. This study was designed to determined whether IIIA-DQB1*0301 is associated with an increased risk of recurrence in melanoma patients presenting with American Joint Committee on Cancer (AJCC) Stage I or II (localized) disease. METHODS. Molecular oligotyping of HLA-DQ genes was performed for 259 patients with AJCC Stage I or II melanoma. Rate of disease recurrence was determined by retrospective review and prospective follow-up, Kaplan-Meier analysis, log rank, and proportional hazard (Cox) comparison were performed. RESULTS. Median follow-up was 24 months. Minimum follow-up was 6 months. Although HLA- DQB1*0301-positive and -negative patients were balanced with regard to standard prognostic factors primary tumor thickness, level of invasion, presence of ulceration, anatomic location, and sex), HLA-DQB1*0301-positive patients were more likely to develop locally recurrent, regional, or distant metastatic melanoma during follow-up (actuarial median disease free survival 48 months [DQB1*0301-positive patients] vs 97 months [DQB1*0301-negative patients log rank P = 0.0002). HLA-DQB1*0301 status, in addition to primary tumor thickness, was an independent prognostic indicator in these patients (Cox multivariate P = 0.02). CONCLUSIONS. Patients-presenting with localized melanoma who carry HLA-DQB1*0301 are at increased risk of developing recurrent disease compared with stage matched patients who lack this allele. HLA-DQB1*0301 is a genomic marker which independently identifies melanoma patients in whom recurrence is more likely, and is potentially useful in selecting those most likely to benefit from adjuvant therapy.
AB - BACKGROUND. Melanoma patients who carry the human leukocyte antigen (HLA) Class II allele DQB1*0301 have an increased frequency of metastases at presentation compared with those lacking HLA-DQB1*0301. This study was designed to determined whether IIIA-DQB1*0301 is associated with an increased risk of recurrence in melanoma patients presenting with American Joint Committee on Cancer (AJCC) Stage I or II (localized) disease. METHODS. Molecular oligotyping of HLA-DQ genes was performed for 259 patients with AJCC Stage I or II melanoma. Rate of disease recurrence was determined by retrospective review and prospective follow-up, Kaplan-Meier analysis, log rank, and proportional hazard (Cox) comparison were performed. RESULTS. Median follow-up was 24 months. Minimum follow-up was 6 months. Although HLA- DQB1*0301-positive and -negative patients were balanced with regard to standard prognostic factors primary tumor thickness, level of invasion, presence of ulceration, anatomic location, and sex), HLA-DQB1*0301-positive patients were more likely to develop locally recurrent, regional, or distant metastatic melanoma during follow-up (actuarial median disease free survival 48 months [DQB1*0301-positive patients] vs 97 months [DQB1*0301-negative patients log rank P = 0.0002). HLA-DQB1*0301 status, in addition to primary tumor thickness, was an independent prognostic indicator in these patients (Cox multivariate P = 0.02). CONCLUSIONS. Patients-presenting with localized melanoma who carry HLA-DQB1*0301 are at increased risk of developing recurrent disease compared with stage matched patients who lack this allele. HLA-DQB1*0301 is a genomic marker which independently identifies melanoma patients in whom recurrence is more likely, and is potentially useful in selecting those most likely to benefit from adjuvant therapy.
KW - MHC Class II
KW - genes
KW - human leukocyte antigen-DQ antigens
KW - melanoma
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U2 - 10.1002/(SICI)1097-0142(19960815)78:4<758::AID-CNCR11>3.0.CO;2-U
DO - 10.1002/(SICI)1097-0142(19960815)78:4<758::AID-CNCR11>3.0.CO;2-U
M3 - Article
C2 - 8756369
AN - SCOPUS:0029742870
SN - 0008-543X
VL - 78
SP - 758
EP - 763
JO - Cancer
JF - Cancer
IS - 4
ER -