TY - JOUR
T1 - Malignant Phyllodes Tumor with Heterologous Osteosarcomatous and Rhabdomyosarcomatous Elements
T2 - A Case Report and Literature Review
AU - Ali, Haval
AU - Moosvi, Ali M.
AU - Zhang, Y. Helen
AU - Sun, Hongxia
N1 - Publisher Copyright:
© 2023 by the Association of Clinical Scientists, Inc.
PY - 2023/1
Y1 - 2023/1
N2 - Phyllodes tumor (PT) is an uncommon fibroepithelial lesion of the breast. PT can be classified as benign, borderline, and malignant based on semi-quantitative assessment of stromal hypercellularity and overgrowth, cytologic atypia, mitotic activity, tumor border, and presence of malignant heterologous elements. PT is considered malignant by default, if malignant heterologous elements are encountered. The heterologous elements include liposarcoma, angiosarcoma, osteosarcoma, chondrosarcoma, and rhabdomyosarcoma. Malignant PT (MPT) with rhabdomyosarcomatous component is extremely rare, and only a few cases are reported. Here, we present a case of MPT with mixed osteosarcomatous and rhabdomyosarcomatous elements in a 51-year-old female, with review of the literatures and discussion of the differential diagnosis.
AB - Phyllodes tumor (PT) is an uncommon fibroepithelial lesion of the breast. PT can be classified as benign, borderline, and malignant based on semi-quantitative assessment of stromal hypercellularity and overgrowth, cytologic atypia, mitotic activity, tumor border, and presence of malignant heterologous elements. PT is considered malignant by default, if malignant heterologous elements are encountered. The heterologous elements include liposarcoma, angiosarcoma, osteosarcoma, chondrosarcoma, and rhabdomyosarcoma. Malignant PT (MPT) with rhabdomyosarcomatous component is extremely rare, and only a few cases are reported. Here, we present a case of MPT with mixed osteosarcomatous and rhabdomyosarcomatous elements in a 51-year-old female, with review of the literatures and discussion of the differential diagnosis.
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M3 - Article
C2 - 36889758
AN - SCOPUS:85149622648
SN - 0091-7370
VL - 53
SP - 159
EP - 163
JO - Annals of clinical and laboratory science
JF - Annals of clinical and laboratory science
IS - 1
ER -