TY - JOUR
T1 - Malignant pleural mesothelioma
AU - Tsao, Anne S.
AU - Wistuba, Ignacio
AU - Roth, Jack A.
AU - Kindler, Hedy Lee
PY - 2009/4/20
Y1 - 2009/4/20
N2 - Malignant pleural mesothelioma (MPM) is a deadly disease that occurs in 2,000 to 3,000 people each year in the United States. Although MPM is an extremely difficult disease to treat, with the median overall survival ranging between 9 and 17 months regardless of stage, there has been significant progress over the last few years that has reshaped the clinical landscape. This article will provide a comprehensive discussion of the latest developments in the treatment of MPM. We will provide an update of the major clinical trials that impact mesothelioma treatment in the resectable and unresectable settings, discuss the impact of novel therapeutics, and provide perspective on where the clinical research in mesothelioma is moving. In addition, there are controversial issues, such as the role of extrapleural pneumonectomy, adjuvant radiotherapy, and use of intensity-modulated radiotherapy versus hemithoracic therapy that will also be addressed
AB - Malignant pleural mesothelioma (MPM) is a deadly disease that occurs in 2,000 to 3,000 people each year in the United States. Although MPM is an extremely difficult disease to treat, with the median overall survival ranging between 9 and 17 months regardless of stage, there has been significant progress over the last few years that has reshaped the clinical landscape. This article will provide a comprehensive discussion of the latest developments in the treatment of MPM. We will provide an update of the major clinical trials that impact mesothelioma treatment in the resectable and unresectable settings, discuss the impact of novel therapeutics, and provide perspective on where the clinical research in mesothelioma is moving. In addition, there are controversial issues, such as the role of extrapleural pneumonectomy, adjuvant radiotherapy, and use of intensity-modulated radiotherapy versus hemithoracic therapy that will also be addressed
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U2 - 10.1200/JCO.2008.19.8523
DO - 10.1200/JCO.2008.19.8523
M3 - Review article
C2 - 19255316
AN - SCOPUS:65349131853
SN - 0732-183X
VL - 27
SP - 2081
EP - 2090
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 12
ER -