Abstract
A low-nicotine cigarette smoke condensate, 12 fractions of the condensate, and a reconstituted sample were tested for their ability to induce transformation in the mouse cell line C3H/10T ½ CL8. This cell line is noted for its remarkably low spontaneous rate of transformation. Both the crude condensate and the reconstituted sample as well as two specific fractions induced transformation in the mouse cells. These transformed cells produced fibrosarcomas when injected s.c. into antithymocyte serum-treated syngeneic mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 857-860 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 35 |
| Issue number | 3 |
| State | Published - Mar 1975 |
ASJC Scopus subject areas
- Oncology
- Cancer Research