TY - JOUR
T1 - MALT lymphoma involving the kidney
T2 - A report of 10 cases and review of the literature
AU - Garcia, Mar
AU - Konoplev, Sergej
AU - Morosan, Cristian
AU - Abruzzo, Lynne V.
AU - Bueso-Ramos, Carlos E.
AU - Medeiros, L. Jeffrey
PY - 2007/9
Y1 - 2007/9
N2 - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) can arise at any anatomic site, but involvement of the kidney is rare. We describe 10 cases of kidney MALT lymphoma, including 6 localized cases. No predisposing inflammatory conditions were identified, with the possible exception of coexistent renal Actinomyces infection in 1 case. We performed fluorescence in situ hybridization (FISH) using a malt/break-apart probe in 7 cases. A malt1 gene rearrangement was identified in I case (14%). This case was further assessed by FISH using an IgH break-apart probe that showed IgH gene rearrangement. These results are suggestive of the t(14;18) involving malt1 and IgH. Immunostaining for NF-κB p65 showed nuclear positivity, consistent with NF-κB activation, in 3 of 5 cases assessed. Our results indicate that kidney MALT lymphomas share similarities with MALT lymphomas arising at other sites in that MALT lymphoma-associated translocations and NF-κB activation occur in a subset of cases.
AB - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) can arise at any anatomic site, but involvement of the kidney is rare. We describe 10 cases of kidney MALT lymphoma, including 6 localized cases. No predisposing inflammatory conditions were identified, with the possible exception of coexistent renal Actinomyces infection in 1 case. We performed fluorescence in situ hybridization (FISH) using a malt/break-apart probe in 7 cases. A malt1 gene rearrangement was identified in I case (14%). This case was further assessed by FISH using an IgH break-apart probe that showed IgH gene rearrangement. These results are suggestive of the t(14;18) involving malt1 and IgH. Immunostaining for NF-κB p65 showed nuclear positivity, consistent with NF-κB activation, in 3 of 5 cases assessed. Our results indicate that kidney MALT lymphomas share similarities with MALT lymphomas arising at other sites in that MALT lymphoma-associated translocations and NF-κB activation occur in a subset of cases.
KW - Chromosomal translocations
KW - Fluorescence in situ hybridization
KW - Kidney
KW - MALT lymphoma
KW - NF-κB
UR - http://www.scopus.com/inward/record.url?scp=34748862543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34748862543&partnerID=8YFLogxK
U2 - 10.1309/0T2UKUKV91W3QR6W
DO - 10.1309/0T2UKUKV91W3QR6W
M3 - Article
C2 - 17709321
AN - SCOPUS:34748862543
SN - 0002-9173
VL - 128
SP - 464
EP - 473
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 3
ER -