MALT lymphoma of the urinary bladder shows a dramatic female predominance, uneven geographic distribution, and possible infectious Etiology

Kirill A. Lyapichev, Yana Ivashkevich, Yaroslav Chernov, Denis Chinenov, Evgeniy Shpot, Alexander A. Bessonov, Bouthaina S. Dabaja, Sergej Konoplev

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the urinary bladder is an extremely rare entity accounting for 0.2% of all malignant urinary bladder neoplasms, and the diagnosis could be challenging. We present here a patient with urinary bladder MALT lymphoma and review of all published case reports in the literature. We summarized the reported immunophe­ notype of the neoplasm, ancillary studies, therapy, and follow-up for all 59 patients in the table. The median patients’ age was 57 years-old (range, 17 to 88), with female predominance in 50 of 59 patients representing a 1:5.6 ratio. Geographical distribution of the reported patients was as follows: 22 from Asia, of which more than a half (16) originated from Japan; 28 from Europe, of which 19 reported from the United Kingdom, and 3 patients were reported from the United States (including our patient). Twenty-three (77%) of 30 patients, for whom their clinical presentation was recorded, had symptoms of cystitis; Escherichia coli was the most common pathogen. We concluded that a prominent female predominance, uneven geographic distribution of urinary bladder MALT lymphoma, and a success of antibacterial therapy in selected cases suggest the link between urinary tract infection and urinary bladder MALT lymphoma.

Original languageEnglish (US)
Pages (from-to)49-62
Number of pages14
JournalResearch and Reports in Urology
Volume13
DOIs
StatePublished - 2021

Keywords

  • Cystitis
  • MALT lymphoma
  • Urinary bladder
  • Urinary tract infection

ASJC Scopus subject areas

  • Urology

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