TY - JOUR
T1 - Mammalian G1 cyclins
AU - Draetta, Giulio F.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1994/12
Y1 - 1994/12
N2 - D- and E-type cyclins regulate the progression of mammalian cells through the G1 phase of the cell cycle. The mechanisms responsible for the accumulation and activation of kinases dependent on cyclins D and E in both normal and cancerous cells have recently been uncovered. Overexpression of cyclin D1 protein as a consequence of genetic rearrangements, and deletions or mutations of the p16INK4 gene have been demonstrated in a large variety of human cancers, including breast and esophageal carcinomas, lymphomas, bladder carcinoma, pancreatic adenocarcinoma and familial melanoma.
AB - D- and E-type cyclins regulate the progression of mammalian cells through the G1 phase of the cell cycle. The mechanisms responsible for the accumulation and activation of kinases dependent on cyclins D and E in both normal and cancerous cells have recently been uncovered. Overexpression of cyclin D1 protein as a consequence of genetic rearrangements, and deletions or mutations of the p16INK4 gene have been demonstrated in a large variety of human cancers, including breast and esophageal carcinomas, lymphomas, bladder carcinoma, pancreatic adenocarcinoma and familial melanoma.
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U2 - 10.1016/0955-0674(94)90054-X
DO - 10.1016/0955-0674(94)90054-X
M3 - Article
C2 - 7880531
AN - SCOPUS:0028172572
SN - 0955-0674
VL - 6
SP - 842
EP - 846
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -