Abstract
Anaplastic large cell lymphoma (ALCL) is one of the most common peripheral T-cell lymphomas, and the incidence is higher in blacks than non-Hispanic whites. ALK-positive and ALK-negative ALCL are distinct subtypes that have different characteristics and clinical outcomes. Breast implant–associated ALCL is a rare lymphoma that has a good survival outcome, and a recent study showed that total capsulectomy is essential for treatment. Brentuximab vedotin (BV) is a standard treatment for relapsed/refractory ALCL. The response rate is high at 80–90%; however, once the disease progresses in patients on BV, survival outcome is very poor, with a median overall survival of less than two months.
Original language | English (US) |
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Pages (from-to) | 209-222 |
Number of pages | 14 |
Journal | Hematology/Oncology Clinics of North America |
Volume | 31 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1 2017 |
Keywords
- Anaplastic large-cell lymphoma
- Brentuximab vedotin
- Stem cell transplant
- Treatment
ASJC Scopus subject areas
- Hematology
- Oncology