TY - JOUR
T1 - Management of Lacrimal Gland Carcinoma
T2 - Lessons from the Literature in the Past 40 Years
AU - Woo, Kyung In
AU - Yeom, Arim
AU - Esmaeli, Bita
N1 - Publisher Copyright:
Copyright © 2015 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Purpose: To review the published literature on management strategies for lacrimal gland carcinomas. Methods: Review of relevant articles in PubMed published in English from the year of 1970 through September 2014. Results: A review of literature suggests that treatment strategies for adenoid cystic carcinoma of lacrimal gland are varied, but local control does not necessarily prevent future delayed distant relapse. Tumor size and histologic features of lacrimal gland carcinoma seem to be important prognostic features. With improved imaging modalities providing better tumor diagnosis and staging, and availability of more focused radiation delivery techniques, multimodality globe sparing management of lacrimal gland carcinomas may be possible in selected cases. The availability of targeted drugs based on the molecular signature of an individual lacrimal gland carcinoma may offer possible targeted treatments for patients with nonresectable or metastatic disease. Conclusion: Given the rarity of lacrimal gland carcinoma, multi-institutional studies and consistent reporting of size and histologic type of tumors in the literature may be prudent. Particularly, multimodality globe-sparing treatment strategies should be studied further.
AB - Purpose: To review the published literature on management strategies for lacrimal gland carcinomas. Methods: Review of relevant articles in PubMed published in English from the year of 1970 through September 2014. Results: A review of literature suggests that treatment strategies for adenoid cystic carcinoma of lacrimal gland are varied, but local control does not necessarily prevent future delayed distant relapse. Tumor size and histologic features of lacrimal gland carcinoma seem to be important prognostic features. With improved imaging modalities providing better tumor diagnosis and staging, and availability of more focused radiation delivery techniques, multimodality globe sparing management of lacrimal gland carcinomas may be possible in selected cases. The availability of targeted drugs based on the molecular signature of an individual lacrimal gland carcinoma may offer possible targeted treatments for patients with nonresectable or metastatic disease. Conclusion: Given the rarity of lacrimal gland carcinoma, multi-institutional studies and consistent reporting of size and histologic type of tumors in the literature may be prudent. Particularly, multimodality globe-sparing treatment strategies should be studied further.
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U2 - 10.1097/IOP.0000000000000531
DO - 10.1097/IOP.0000000000000531
M3 - Review article
C2 - 26291539
AN - SCOPUS:84954448017
SN - 0740-9303
VL - 32
SP - 1
EP - 10
JO - Ophthalmic plastic and reconstructive surgery
JF - Ophthalmic plastic and reconstructive surgery
IS - 1
ER -