TY - JOUR
T1 - Management of Older Men With Clinically Localized Prostate Cancer
T2 - The Significance of Advanced Age and Comorbidity
AU - Hoffman, Karen E.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/10
Y1 - 2012/10
N2 - The majority of men diagnosed with prostate cancer are diagnosed later in life. Although localized prostate cancer is often an indolent disease, older men are more frequently diagnosed with high-risk disease and are more likely to die from prostate cancer than younger men. Comorbid medical conditions are also more prevalent in the later decades of life and can impact prostate cancer treatment tolerance and the likelihood of benefiting from aggressive cancer treatment. Older men diagnosed with prostate cancer are at risk for both overtreatment of low-risk disease and undertreatment of high-risk disease. Prostate cancer management decisions for older patients should be tailored based on an individual patient's health status, coexisting medical conditions, life expectancy, and tumor characteristics.
AB - The majority of men diagnosed with prostate cancer are diagnosed later in life. Although localized prostate cancer is often an indolent disease, older men are more frequently diagnosed with high-risk disease and are more likely to die from prostate cancer than younger men. Comorbid medical conditions are also more prevalent in the later decades of life and can impact prostate cancer treatment tolerance and the likelihood of benefiting from aggressive cancer treatment. Older men diagnosed with prostate cancer are at risk for both overtreatment of low-risk disease and undertreatment of high-risk disease. Prostate cancer management decisions for older patients should be tailored based on an individual patient's health status, coexisting medical conditions, life expectancy, and tumor characteristics.
UR - http://www.scopus.com/inward/record.url?scp=84866317945&partnerID=8YFLogxK
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U2 - 10.1016/j.semradonc.2012.05.005
DO - 10.1016/j.semradonc.2012.05.005
M3 - Review article
C2 - 22985811
AN - SCOPUS:84866317945
SN - 1053-4296
VL - 22
SP - 284
EP - 294
JO - Seminars in radiation oncology
JF - Seminars in radiation oncology
IS - 4
ER -