TY - JOUR
T1 - Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult
T2 - An Updated Consensus Approach from the Transatlantic Australasian RPS Working Group
AU - on behalf of the Transatlantic Australasian RPS Working Group (TARPSWG)
AU - Swallow, Carol J.
AU - Strauss, Dirk C.
AU - Bonvalot, Sylvie
AU - Rutkowski, Piotr
AU - Desai, Anant
AU - Gladdy, Rebecca A.
AU - Gonzalez, Ricardo
AU - Gyorki, David E.
AU - Fairweather, Mark
AU - van Houdt, Winan J.
AU - Stoeckle, Eberhard
AU - Park, Jae Berm
AU - Albertsmeier, Markus
AU - Nessim, Carolyn
AU - Cardona, Kenneth
AU - Fiore, Marco
AU - Hayes, Andrew
AU - Tzanis, Dimitri
AU - Skoczylas, Jacek
AU - Ford, Samuel J.
AU - Ng, Deanna
AU - Mullinax, John E.
AU - Snow, Hayden
AU - Haas, Rick L.
AU - Callegaro, Dario
AU - Smith, Myles J.
AU - Bouhadiba, Toufik
AU - Stacchiotti, Silvia
AU - Jones, Robin L.
AU - DeLaney, Thomas
AU - Roland, Christina L.
AU - Raut, Chandrajit P.
AU - Gronchi, Alessandro
N1 - Publisher Copyright:
© 2021, Society of Surgical Oncology.
PY - 2021/11
Y1 - 2021/11
N2 - Background: Retroperitoneal soft tissue sarcomas comprise a heterogeneous group of rare tumors of mesenchymal origin that include several well-defined histologic subtypes. In 2015, the Transatlantic Australasian RPS Working Group (TARPSWG) published consensus recommendations for the best management of primary retroperitoneal sarcoma (RPS). Since then, through international collaboration, new evidence and knowledge have been generated, creating the need for an updated consensus document. Methods: The primary aim of this study was to critically evaluate the current evidence and develop an up-to-date consensus document on the approach to these difficult tumors. The resulting document applies to primary RPS that is non-visceral in origin, with exclusion criteria as previously described. The relevant literature was evaluated and an international group of experts consulted to formulate consensus statements regarding the best management of primary RPS. A level of evidence and grade of recommendation were attributed to each new/updated recommendation. Results: Management of primary RPS was considered from diagnosis to follow-up. This rare and complex malignancy is best managed by an experienced multidisciplinary team in a specialized referral center. The best chance of cure is at the time of primary presentation, and an individualized management plan should be made based on the 29 consensus statements included in this article, which were agreed upon by all of the authors. Whenever possible, patients should be enrolled in prospective trials and studies. Conclusions: Ongoing international collaboration is critical to expand upon current knowledge and further improve outcomes of patients with RPS. In addition, prospective data collection and participation in multi-institution trials are strongly encouraged.
AB - Background: Retroperitoneal soft tissue sarcomas comprise a heterogeneous group of rare tumors of mesenchymal origin that include several well-defined histologic subtypes. In 2015, the Transatlantic Australasian RPS Working Group (TARPSWG) published consensus recommendations for the best management of primary retroperitoneal sarcoma (RPS). Since then, through international collaboration, new evidence and knowledge have been generated, creating the need for an updated consensus document. Methods: The primary aim of this study was to critically evaluate the current evidence and develop an up-to-date consensus document on the approach to these difficult tumors. The resulting document applies to primary RPS that is non-visceral in origin, with exclusion criteria as previously described. The relevant literature was evaluated and an international group of experts consulted to formulate consensus statements regarding the best management of primary RPS. A level of evidence and grade of recommendation were attributed to each new/updated recommendation. Results: Management of primary RPS was considered from diagnosis to follow-up. This rare and complex malignancy is best managed by an experienced multidisciplinary team in a specialized referral center. The best chance of cure is at the time of primary presentation, and an individualized management plan should be made based on the 29 consensus statements included in this article, which were agreed upon by all of the authors. Whenever possible, patients should be enrolled in prospective trials and studies. Conclusions: Ongoing international collaboration is critical to expand upon current knowledge and further improve outcomes of patients with RPS. In addition, prospective data collection and participation in multi-institution trials are strongly encouraged.
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U2 - 10.1245/s10434-021-09654-z
DO - 10.1245/s10434-021-09654-z
M3 - Article
C2 - 33852100
AN - SCOPUS:85104680786
SN - 1068-9265
VL - 28
SP - 7873
EP - 7888
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 12
ER -