Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer

Israel Pena; Gary L. Clayman; Elizabeth G. Grubbs; Jeffrey M. Bergeron; Steven G. Waguespack; Maria E. Cabanillas; Ramona Dadu; Mimi I. Hu; Bryan M. Fellman; Yisheng Li; Neil D. Gross; Stephen Y. Lai; Erich M. Sturgis; Mark E. Zafereo

doi:10.1002/hed.24969

Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer

Israel Pena, Gary L. Clayman, Elizabeth G. Grubbs, Jeffrey M. Bergeron, Steven G. Waguespack, Maria E. Cabanillas, Ramona Dadu, Mimi I. Hu, Bryan M. Fellman, Yisheng Li, Neil D. Gross, Stephen Y. Lai, Erich M. Sturgis, Mark E. Zafereo

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background: The purpose of this retrospective analysis was to evaluate the benefits of an elective lateral neck dissection (ELND) in patients with medullary thyroid cancer (MTC) without radiographically apparent lateral neck metastases. Methods: Patients with sporadic MTC without radiographic evidence of lateral neck metastasis who underwent definitive surgery were divided into 2 groups based on surgical approach: no ELND (the observation group) and ipsilateral or bilateral ELND (the ELND group). Primary outcomes were biochemical cure, locoregional recurrence, distant metastasis, and overall survival (OS). Results: Sixty-six patients met inclusion criteria: 44 patients (67%) in the observation group and 22 patients (33%) in the ELND group. Two of 44 patients (5%) in the observation group developed subsequent (ipsilateral) lateral neck disease. At last follow-up, locoregional disease control rates among the observation and ELND groups were 98% and 100% (P >.999), respectively, whereas biochemical cure rates were 82% and 85% (P >.999), respectively, and 5-year OSs were 84% and 100% (P =.156), respectively. Conclusion: Patients with MTC without lateral neck metastasis have similar biochemical cure rates with observation or elective dissection of lateral neck compartments.

Original language	English (US)
Pages (from-to)	79-85
Number of pages	7
Journal	Head and Neck
Volume	40
Issue number	1
DOIs	https://doi.org/10.1002/hed.24969
State	Published - Jan 2018

Keywords

American Thyroid Association
calcitonin
elective neck dissection
observation
regional metastases

ASJC Scopus subject areas

Otorhinolaryngology

MD Anderson CCSG core facilities

Biostatistics Resource Group

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10.1002/hed.24969

Cite this

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title = "Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer",

abstract = "Background: The purpose of this retrospective analysis was to evaluate the benefits of an elective lateral neck dissection (ELND) in patients with medullary thyroid cancer (MTC) without radiographically apparent lateral neck metastases. Methods: Patients with sporadic MTC without radiographic evidence of lateral neck metastasis who underwent definitive surgery were divided into 2 groups based on surgical approach: no ELND (the observation group) and ipsilateral or bilateral ELND (the ELND group). Primary outcomes were biochemical cure, locoregional recurrence, distant metastasis, and overall survival (OS). Results: Sixty-six patients met inclusion criteria: 44 patients (67%) in the observation group and 22 patients (33%) in the ELND group. Two of 44 patients (5%) in the observation group developed subsequent (ipsilateral) lateral neck disease. At last follow-up, locoregional disease control rates among the observation and ELND groups were 98% and 100% (P >.999), respectively, whereas biochemical cure rates were 82% and 85% (P >.999), respectively, and 5-year OSs were 84% and 100% (P =.156), respectively. Conclusion: Patients with MTC without lateral neck metastasis have similar biochemical cure rates with observation or elective dissection of lateral neck compartments.",

keywords = "American Thyroid Association, calcitonin, elective neck dissection, observation, regional metastases",

author = "Israel Pena and Clayman, {Gary L.} and Grubbs, {Elizabeth G.} and Bergeron, {Jeffrey M.} and Waguespack, {Steven G.} and Cabanillas, {Maria E.} and Ramona Dadu and Hu, {Mimi I.} and Fellman, {Bryan M.} and Yisheng Li and Gross, {Neil D.} and Lai, {Stephen Y.} and Sturgis, {Erich M.} and Zafereo, {Mark E.}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2018",

month = jan,

doi = "10.1002/hed.24969",

language = "English (US)",

volume = "40",

pages = "79--85",

journal = "Head and Neck",

issn = "1043-3074",

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T1 - Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer

AU - Pena, Israel

AU - Clayman, Gary L.

AU - Grubbs, Elizabeth G.

AU - Bergeron, Jeffrey M.

AU - Waguespack, Steven G.

AU - Cabanillas, Maria E.

AU - Dadu, Ramona

AU - Hu, Mimi I.

AU - Fellman, Bryan M.

AU - Li, Yisheng

AU - Gross, Neil D.

AU - Lai, Stephen Y.

AU - Sturgis, Erich M.

AU - Zafereo, Mark E.

PY - 2018/1

Y1 - 2018/1

N2 - Background: The purpose of this retrospective analysis was to evaluate the benefits of an elective lateral neck dissection (ELND) in patients with medullary thyroid cancer (MTC) without radiographically apparent lateral neck metastases. Methods: Patients with sporadic MTC without radiographic evidence of lateral neck metastasis who underwent definitive surgery were divided into 2 groups based on surgical approach: no ELND (the observation group) and ipsilateral or bilateral ELND (the ELND group). Primary outcomes were biochemical cure, locoregional recurrence, distant metastasis, and overall survival (OS). Results: Sixty-six patients met inclusion criteria: 44 patients (67%) in the observation group and 22 patients (33%) in the ELND group. Two of 44 patients (5%) in the observation group developed subsequent (ipsilateral) lateral neck disease. At last follow-up, locoregional disease control rates among the observation and ELND groups were 98% and 100% (P >.999), respectively, whereas biochemical cure rates were 82% and 85% (P >.999), respectively, and 5-year OSs were 84% and 100% (P =.156), respectively. Conclusion: Patients with MTC without lateral neck metastasis have similar biochemical cure rates with observation or elective dissection of lateral neck compartments.

AB - Background: The purpose of this retrospective analysis was to evaluate the benefits of an elective lateral neck dissection (ELND) in patients with medullary thyroid cancer (MTC) without radiographically apparent lateral neck metastases. Methods: Patients with sporadic MTC without radiographic evidence of lateral neck metastasis who underwent definitive surgery were divided into 2 groups based on surgical approach: no ELND (the observation group) and ipsilateral or bilateral ELND (the ELND group). Primary outcomes were biochemical cure, locoregional recurrence, distant metastasis, and overall survival (OS). Results: Sixty-six patients met inclusion criteria: 44 patients (67%) in the observation group and 22 patients (33%) in the ELND group. Two of 44 patients (5%) in the observation group developed subsequent (ipsilateral) lateral neck disease. At last follow-up, locoregional disease control rates among the observation and ELND groups were 98% and 100% (P >.999), respectively, whereas biochemical cure rates were 82% and 85% (P >.999), respectively, and 5-year OSs were 84% and 100% (P =.156), respectively. Conclusion: Patients with MTC without lateral neck metastasis have similar biochemical cure rates with observation or elective dissection of lateral neck compartments.

KW - American Thyroid Association

KW - calcitonin

KW - elective neck dissection

KW - observation

KW - regional metastases

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Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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