Management of the Neck in Well-Differentiated Thyroid Cancer

Panagiotis Asimakopoulos; Ashok R. Shaha; Iain J. Nixon; Jatin P. Shah; Gregory W. Randolph; Peter Angelos; Mark E. Zafereo; Luiz P. Kowalski; Dana M. Hartl; Kerry D. Olsen; Juan P. Rodrigo; Vincent Vander Poorten; Antti A. Mäkitie; Alvaro Sanabria; Carlos Suárez; Miquel Quer; Francisco J. Civantos; K. Thomas Robbins; Orlando Guntinas-Lichius; Marc Hamoir; Alessandra Rinaldo; Alfio Ferlito

doi:10.1007/s11912-020-00997-6

Management of the Neck in Well-Differentiated Thyroid Cancer

Panagiotis Asimakopoulos, Ashok R. Shaha, Iain J. Nixon, Jatin P. Shah, Gregory W. Randolph, Peter Angelos, Mark E. Zafereo, Luiz P. Kowalski, Dana M. Hartl, Kerry D. Olsen, Juan P. Rodrigo, Vincent Vander Poorten, Antti A. Mäkitie, Alvaro Sanabria, Carlos Suárez, Miquel Quer, Francisco J. Civantos, K. Thomas Robbins, Orlando Guntinas-Lichius, Marc HamoirAlessandra Rinaldo, Alfio Ferlito

Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Purpose of Review: In this narrative review, we discuss the indications for elective and therapeutic neck dissections and the postoperative surveillance and treatment options for recurrent nodal disease in patients with well-differentiated thyroid cancer. Recent Findings: Increased availability of advanced imaging modalities has led to an increased detection rate of previously occult nodal disease in thyroid cancer. Nodal metastases are more common in young patients, large primary tumors, specific genotypes, and certain histological types. While clinically evident nodal disease in the lateral neck compartments has a significant oncological impact, particularly in the older age group, microscopic metastases to the central or the lateral neck in well-differentiated thyroid cancer do not significantly affect outcome. Summary: As patients with clinically evident nodal disease are associated with worse outcomes, they should be treated surgically in order to reduce rates of regional recurrence and improve survival. The benefit of elective neck dissection remains unverified as the impact of microscopic disease on outcomes is not significant.

Original language	English (US)
Article number	1
Journal	Current oncology reports
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/s11912-020-00997-6
State	Published - Jan 2021

Keywords

Lymphatic metastasis
Neck dissection
Thyroid neoplasms

ASJC Scopus subject areas

Oncology

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10.1007/s11912-020-00997-6

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Asimakopoulos, P., Shaha, A. R., Nixon, I. J., Shah, J. P., Randolph, G. W., Angelos, P., Zafereo, M. E., Kowalski, L. P., Hartl, D. M., Olsen, K. D., Rodrigo, J. P., Vander Poorten, V., Mäkitie, A. A., Sanabria, A., Suárez, C., Quer, M., Civantos, F. J., Robbins, K. T., Guntinas-Lichius, O., ... Ferlito, A. (2021). Management of the Neck in Well-Differentiated Thyroid Cancer. Current oncology reports, 23(1), Article 1. https://doi.org/10.1007/s11912-020-00997-6

Asimakopoulos, P, Shaha, AR, Nixon, IJ, Shah, JP, Randolph, GW, Angelos, P, Zafereo, ME, Kowalski, LP, Hartl, DM, Olsen, KD, Rodrigo, JP, Vander Poorten, V, Mäkitie, AA, Sanabria, A, Suárez, C, Quer, M, Civantos, FJ, Robbins, KT, Guntinas-Lichius, O, Hamoir, M, Rinaldo, A & Ferlito, A 2021, 'Management of the Neck in Well-Differentiated Thyroid Cancer', Current oncology reports, vol. 23, no. 1, 1. https://doi.org/10.1007/s11912-020-00997-6

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title = "Management of the Neck in Well-Differentiated Thyroid Cancer",

abstract = "Purpose of Review: In this narrative review, we discuss the indications for elective and therapeutic neck dissections and the postoperative surveillance and treatment options for recurrent nodal disease in patients with well-differentiated thyroid cancer. Recent Findings: Increased availability of advanced imaging modalities has led to an increased detection rate of previously occult nodal disease in thyroid cancer. Nodal metastases are more common in young patients, large primary tumors, specific genotypes, and certain histological types. While clinically evident nodal disease in the lateral neck compartments has a significant oncological impact, particularly in the older age group, microscopic metastases to the central or the lateral neck in well-differentiated thyroid cancer do not significantly affect outcome. Summary: As patients with clinically evident nodal disease are associated with worse outcomes, they should be treated surgically in order to reduce rates of regional recurrence and improve survival. The benefit of elective neck dissection remains unverified as the impact of microscopic disease on outcomes is not significant.",

keywords = "Lymphatic metastasis, Neck dissection, Thyroid neoplasms",

author = "Panagiotis Asimakopoulos and Shaha, {Ashok R.} and Nixon, {Iain J.} and Shah, {Jatin P.} and Randolph, {Gregory W.} and Peter Angelos and Zafereo, {Mark E.} and Kowalski, {Luiz P.} and Hartl, {Dana M.} and Olsen, {Kerry D.} and Rodrigo, {Juan P.} and {Vander Poorten}, Vincent and M{\"a}kitie, {Antti A.} and Alvaro Sanabria and Carlos Su{\'a}rez and Miquel Quer and Civantos, {Francisco J.} and Robbins, {K. Thomas} and Orlando Guntinas-Lichius and Marc Hamoir and Alessandra Rinaldo and Alfio Ferlito",

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year = "2021",

month = jan,

doi = "10.1007/s11912-020-00997-6",

language = "English (US)",

volume = "23",

journal = "Current oncology reports",

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AU - Asimakopoulos, Panagiotis

AU - Shaha, Ashok R.

AU - Nixon, Iain J.

AU - Shah, Jatin P.

AU - Randolph, Gregory W.

AU - Angelos, Peter

AU - Zafereo, Mark E.

AU - Kowalski, Luiz P.

AU - Hartl, Dana M.

AU - Olsen, Kerry D.

AU - Rodrigo, Juan P.

AU - Vander Poorten, Vincent

AU - Mäkitie, Antti A.

AU - Sanabria, Alvaro

AU - Suárez, Carlos

AU - Quer, Miquel

AU - Civantos, Francisco J.

AU - Robbins, K. Thomas

AU - Guntinas-Lichius, Orlando

AU - Hamoir, Marc

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2021/1

Y1 - 2021/1

N2 - Purpose of Review: In this narrative review, we discuss the indications for elective and therapeutic neck dissections and the postoperative surveillance and treatment options for recurrent nodal disease in patients with well-differentiated thyroid cancer. Recent Findings: Increased availability of advanced imaging modalities has led to an increased detection rate of previously occult nodal disease in thyroid cancer. Nodal metastases are more common in young patients, large primary tumors, specific genotypes, and certain histological types. While clinically evident nodal disease in the lateral neck compartments has a significant oncological impact, particularly in the older age group, microscopic metastases to the central or the lateral neck in well-differentiated thyroid cancer do not significantly affect outcome. Summary: As patients with clinically evident nodal disease are associated with worse outcomes, they should be treated surgically in order to reduce rates of regional recurrence and improve survival. The benefit of elective neck dissection remains unverified as the impact of microscopic disease on outcomes is not significant.

AB - Purpose of Review: In this narrative review, we discuss the indications for elective and therapeutic neck dissections and the postoperative surveillance and treatment options for recurrent nodal disease in patients with well-differentiated thyroid cancer. Recent Findings: Increased availability of advanced imaging modalities has led to an increased detection rate of previously occult nodal disease in thyroid cancer. Nodal metastases are more common in young patients, large primary tumors, specific genotypes, and certain histological types. While clinically evident nodal disease in the lateral neck compartments has a significant oncological impact, particularly in the older age group, microscopic metastases to the central or the lateral neck in well-differentiated thyroid cancer do not significantly affect outcome. Summary: As patients with clinically evident nodal disease are associated with worse outcomes, they should be treated surgically in order to reduce rates of regional recurrence and improve survival. The benefit of elective neck dissection remains unverified as the impact of microscopic disease on outcomes is not significant.

KW - Lymphatic metastasis

KW - Neck dissection

KW - Thyroid neoplasms

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Management of the Neck in Well-Differentiated Thyroid Cancer

Abstract

Keywords

ASJC Scopus subject areas

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