Mantle cell lymphoma as a component of composite lymphoma: Clinicopathologic parameters and biologic implications

Thomas G. Papathomas; Ioannis Venizelos; Cherie H. Dunphy; Jonathan W. Said; Michael L. Wang; Elias Campo; Steven H. Swerdlow; John C. Chan; Carlos E. Bueso-Ramos; Dennis D. Weisenburger; L. Jeffrey Medeiros; Ken H. Young

doi:10.1016/j.humpath.2011.08.024

Mantle cell lymphoma as a component of composite lymphoma: Clinicopathologic parameters and biologic implications

Thomas G. Papathomas, Ioannis Venizelos, Cherie H. Dunphy, Jonathan W. Said, Michael L. Wang, Elias Campo, Steven H. Swerdlow, John C. Chan, Carlos E. Bueso-Ramos, Dennis D. Weisenburger, L. Jeffrey Medeiros, Ken H. Young

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified with the advent of molecular genetic techniques, this topic has only rarely been a specific focus of the medical scientific literature. In this review, we focus on mantle cell lymphoma occurring as a major pathologic component of composite lymphoma and emphasize the clinicopathologic features of these tumors and associated biologic implications. To date, 26 cases of composite lymphoma including a component of mantle cell lymphoma have been previously published. Issues of clonal relatedness between the individual lymphoma components and emerging biologic implications as well as potential diagnostic pitfalls are evaluated.

Original language	English (US)
Pages (from-to)	467-480
Number of pages	14
Journal	Human Pathology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.humpath.2011.08.024
State	Published - Apr 2012

Keywords

Burkitt lymphoma
Chronic lymphocytic leukemia
Classical Hodgkin lymphoma
Clonal relationship
Composite lymphoma
Follicular lymphoma
Mantle cell lymphoma
Marginal zone lymphoma
Plasma cell neoplasm
Plasmablastic lymphoma
Small lymphocytic lymphoma

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.humpath.2011.08.024

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Papathomas, T. G., Venizelos, I., Dunphy, C. H., Said, J. W., Wang, M. L., Campo, E., Swerdlow, S. H., Chan, J. C., Bueso-Ramos, C. E., Weisenburger, D. D., Medeiros, L. J., & Young, K. H. (2012). Mantle cell lymphoma as a component of composite lymphoma: Clinicopathologic parameters and biologic implications. Human Pathology, 43(4), 467-480. https://doi.org/10.1016/j.humpath.2011.08.024

Papathomas, TG, Venizelos, I, Dunphy, CH, Said, JW, Wang, ML, Campo, E, Swerdlow, SH, Chan, JC, Bueso-Ramos, CE, Weisenburger, DD, Medeiros, LJ & Young, KH 2012, 'Mantle cell lymphoma as a component of composite lymphoma: Clinicopathologic parameters and biologic implications', Human Pathology, vol. 43, no. 4, pp. 467-480. https://doi.org/10.1016/j.humpath.2011.08.024

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abstract = "Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified with the advent of molecular genetic techniques, this topic has only rarely been a specific focus of the medical scientific literature. In this review, we focus on mantle cell lymphoma occurring as a major pathologic component of composite lymphoma and emphasize the clinicopathologic features of these tumors and associated biologic implications. To date, 26 cases of composite lymphoma including a component of mantle cell lymphoma have been previously published. Issues of clonal relatedness between the individual lymphoma components and emerging biologic implications as well as potential diagnostic pitfalls are evaluated.",

keywords = "Burkitt lymphoma, Chronic lymphocytic leukemia, Classical Hodgkin lymphoma, Clonal relationship, Composite lymphoma, Follicular lymphoma, Mantle cell lymphoma, Marginal zone lymphoma, Plasma cell neoplasm, Plasmablastic lymphoma, Small lymphocytic lymphoma",

author = "Papathomas, {Thomas G.} and Ioannis Venizelos and Dunphy, {Cherie H.} and Said, {Jonathan W.} and Wang, {Michael L.} and Elias Campo and Swerdlow, {Steven H.} and Chan, {John C.} and Bueso-Ramos, {Carlos E.} and Weisenburger, {Dennis D.} and Medeiros, {L. Jeffrey} and Young, {Ken H.}",

note = "Funding Information: The study is supported by The University of Texas MD Anderson Cancer Center Institutional R&D Fund, The University of Texas MD Anderson Cancer Center Institutional Research Grant Award, The myeloma SPORE Research Development Program Award, Gundersen Medical Foundation Award, and Forward Lymphoma Fund. This study is also partially supported by NCI/NIH ( R01CA138688 and 1RC1CA146299 ). ",

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AU - Bueso-Ramos, Carlos E.

AU - Weisenburger, Dennis D.

AU - Medeiros, L. Jeffrey

AU - Young, Ken H.

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Mantle cell lymphoma as a component of composite lymphoma: Clinicopathologic parameters and biologic implications

Abstract

Keywords

ASJC Scopus subject areas

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