TY - JOUR
T1 - Mapping anti-müllerian hormone (amh) and related sequences in the mouse
T2 - Identification of a new region of homology between MMU10 and HSA19p
AU - King, Thomas R.
AU - Lee, Barbara K.
AU - Behringer, Richard R.
AU - Eicher, Eva M.
N1 - Funding Information:
We are grateful to Richard Cate, Stewart Lyman, J. David McDonald, Kiran Chada, and Colin Bishop for supplying probes for Amh, Mgf, Pa/z, pg, and Zfa, respectively; Michelle Higgins, David Hale, and Linda Washburn for mouse production and DNA isolation; and David Hale for providing Southern blots of standard inbred and wild-derived inbred strains. We also thank Janan Ep-pig, Joseph Nadeau, and Linda Washburn for reviewing the manuscript. This work was supported in part by Grant GM20919 (B.K.L. and E.M.E.) and Training Grant CA09217 (T.R.K.) from the National Institutes of Health.
PY - 1991/10
Y1 - 1991/10
N2 - A panel of 78 backcross progeny, BALB cJ × ( BALB cJ × CAST Ei)F1 was used to map the gene encoding anti-Müllerian hormone (Amh), also called Müllerian inhibiting substance, to mouse Chromosome 10 (MMU10). This analysis identified a new region of linkage homology between human Chromosome 19p (HSA 19p) and MMU10 and localized an apparent recombinational hot spot in ( C57BL 6J × Mus spretus)F1 females [compared with ( BALB cJ × CAST Ei)F1 males] to the interval between phenylalanine hydroxylase (Pah) and mast cell growth factor (Mgf). In addition, eight unlinked polymorphic sequences, provisionally designated Amh-related sequences (Amh-rs1 through Amh-rs8), were identified by Southern blot analysis using Amh probes. Amh-rs1, -rs2, -rs4, and -rs7 were mapped to MMU1, 13, 12, and 15, respectively, by recombinant inbred (RI) strain and intraspecific backcross analyses. The NXSM RI strain distribution patterns for the four unmapped loci are also presented.
AB - A panel of 78 backcross progeny, BALB cJ × ( BALB cJ × CAST Ei)F1 was used to map the gene encoding anti-Müllerian hormone (Amh), also called Müllerian inhibiting substance, to mouse Chromosome 10 (MMU10). This analysis identified a new region of linkage homology between human Chromosome 19p (HSA 19p) and MMU10 and localized an apparent recombinational hot spot in ( C57BL 6J × Mus spretus)F1 females [compared with ( BALB cJ × CAST Ei)F1 males] to the interval between phenylalanine hydroxylase (Pah) and mast cell growth factor (Mgf). In addition, eight unlinked polymorphic sequences, provisionally designated Amh-related sequences (Amh-rs1 through Amh-rs8), were identified by Southern blot analysis using Amh probes. Amh-rs1, -rs2, -rs4, and -rs7 were mapped to MMU1, 13, 12, and 15, respectively, by recombinant inbred (RI) strain and intraspecific backcross analyses. The NXSM RI strain distribution patterns for the four unmapped loci are also presented.
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U2 - 10.1016/0888-7543(91)90133-Y
DO - 10.1016/0888-7543(91)90133-Y
M3 - Article
C2 - 1685136
AN - SCOPUS:0025917832
SN - 0888-7543
VL - 11
SP - 273
EP - 283
JO - Genomics
JF - Genomics
IS - 2
ER -