Abstract
To test models of T-cell recognition, mice transgenic for T-cell receptor α or β chain have been immunized with variant peptides that force changes in the resulting T-cell response. In particular, charge substitutions on the peptide often elicit reciprocal charges in the junctional (CDR3) sequences of T-cell receptor Vαor Vβ chains, indicating direct T-cell receptor-peptide contact, and allowing derivation of a topology for the T-cell receptor-MHC interaction. At one position on the peptide, variants transformed a homogeneous Vβ response into a very heterogeneous one.
Original language | English (US) |
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Pages (from-to) | 224-230 |
Number of pages | 7 |
Journal | Nature |
Volume | 355 |
Issue number | 6357 |
DOIs | |
State | Published - 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- General