Mapping the Lineage Relationship between CXCR5+ and CXCR5− CD4+ T Cells in HIV-Infected Human Lymph Nodes

Daniel Del Alcazar; Yifeng Wang; Chenfeng He; Ben S. Wendel; Perla M. Del Río-Estrada; Jerome Lin; Yuria Ablanedo-Terrazas; Michael J. Malone; Stefany M. Hernandez; Ian Frank; Ali Naji; Gustavo Reyes-Terán; Ning Jiang; Laura F. Su

doi:10.1016/j.celrep.2019.08.037

Mapping the Lineage Relationship between CXCR5⁺ and CXCR5⁻ CD4⁺ T Cells in HIV-Infected Human Lymph Nodes

Daniel Del Alcazar, Yifeng Wang, Chenfeng He, Ben S. Wendel, Perla M. Del Río-Estrada, Jerome Lin, Yuria Ablanedo-Terrazas, Michael J. Malone, Stefany M. Hernandez, Ian Frank, Ali Naji, Gustavo Reyes-Terán, Ning Jiang, Laura F. Su

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Follicular helper T (T_FH) cells are critical for antibody production. Del Alcazar et al. showed that T_FH cells can lose their characteristic chemokine receptor, giving rise to migratory populations of CXCR5⁻ T cells that retain B cell help function and are poised for CXCR5 expression.

Original language	English (US)
Pages (from-to)	3047-3060.e7
Journal	Cell Reports
Volume	28
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2019.08.037
State	Published - Sep 17 2019
Externally published	Yes

Keywords

HIV
T-bet+ B cells
chronic inflammation
follicular helper T cells
human
infection
lymph node
mass cytometry
migration

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2019.08.037

Cite this

Del Alcazar, D., Wang, Y., He, C., Wendel, B. S., Del Río-Estrada, P. M., Lin, J., Ablanedo-Terrazas, Y., Malone, M. J., Hernandez, S. M., Frank, I., Naji, A., Reyes-Terán, G., Jiang, N., & Su, L. F. (2019). Mapping the Lineage Relationship between CXCR5⁺ and CXCR5⁻ CD4⁺ T Cells in HIV-Infected Human Lymph Nodes. Cell Reports, 28(12), 3047-3060.e7. https://doi.org/10.1016/j.celrep.2019.08.037

Del Alcazar, D, Wang, Y, He, C, Wendel, BS, Del Río-Estrada, PM, Lin, J, Ablanedo-Terrazas, Y, Malone, MJ, Hernandez, SM, Frank, I, Naji, A, Reyes-Terán, G, Jiang, N & Su, LF 2019, 'Mapping the Lineage Relationship between CXCR5⁺ and CXCR5⁻ CD4⁺ T Cells in HIV-Infected Human Lymph Nodes', Cell Reports, vol. 28, no. 12, pp. 3047-3060.e7. https://doi.org/10.1016/j.celrep.2019.08.037

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title = "Mapping the Lineage Relationship between CXCR5+ and CXCR5− CD4+ T Cells in HIV-Infected Human Lymph Nodes",

abstract = "Follicular helper T (TFH) cells are critical for antibody production. Del Alcazar et al. showed that TFH cells can lose their characteristic chemokine receptor, giving rise to migratory populations of CXCR5− T cells that retain B cell help function and are poised for CXCR5 expression.",

keywords = "HIV, T-bet+ B cells, chronic inflammation, follicular helper T cells, human, infection, lymph node, mass cytometry, migration",

author = "{Del Alcazar}, Daniel and Yifeng Wang and Chenfeng He and Wendel, {Ben S.} and {Del R{\'i}o-Estrada}, {Perla M.} and Jerome Lin and Yuria Ablanedo-Terrazas and Malone, {Michael J.} and Hernandez, {Stefany M.} and Ian Frank and Ali Naji and Gustavo Reyes-Ter{\'a}n and Ning Jiang and Su, {Laura F.}",

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AU - Wendel, Ben S.

AU - Del Río-Estrada, Perla M.

AU - Lin, Jerome

AU - Ablanedo-Terrazas, Yuria

AU - Malone, Michael J.

AU - Hernandez, Stefany M.

AU - Frank, Ian

AU - Naji, Ali

AU - Reyes-Terán, Gustavo

AU - Jiang, Ning

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KW - follicular helper T cells

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KW - lymph node

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