Mass spectrometry-based stable-isotope tracing uncovers metabolic alterations in pyruvate kinase-deficient Aedes aegypti mosquitoes

Medicine & Life Sciences

• Pyruvate Kinase 100%
• Aedes 96%
• Isotopes 83%
• Culicidae 82%
• Mass Spectrometry 69%
• Sucrose 18%
• malate dehydrogenase (decarboxylating) 18%
• malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) 18%
• Phosphoglycerate Dehydrogenase 16%
• Pyruvate Kinase Deficiency of Red Cells 16%
• Glutamate Dehydrogenase 13%
• Fat Body 13%
• Gene Expression 11%
• Ammonia 10%
• Metabolic Networks and Pathways 9%
• Carbon 9%
• Nitrogen 9%
• RNA Interference 9%
• Proteins 7%
• Glucose 6%
• Messenger RNA 5%
• Enzymes 5%
• In Vitro Techniques 4%

Agriculture & Biology

• pyruvate kinase 91%
• Aedes aegypti 81%
• stable isotopes 80%
• Culicidae 66%
• mass spectrometry 65%
• phosphoglycerate dehydrogenase 14%
• sucrose 12%
• gene expression 10%
• malic enzyme 10%
• blood 10%
• glutamate dehydrogenase 9%
• carbon metabolism 9%
• nitrogen metabolism 9%
• fat body 9%
• RNA interference 8%
• plasticity 7%
• tissues 7%
• ammonia 7%
• biochemical pathways 7%
• survival rate 7%
• protein synthesis 6%
• oxidation 6%
• glucose 5%
• enzymes 3%
• proteins 2%
• methodology 2%

Chemistry

• Stable Isotope 84%
• Pyruvate 80%
• Metabolic 62%
• Phosphoglycerate 12%
• Phosphoenolpyruvate 11%
• Plastic Property 9%
• Effector 9%
• Sucrose 8%
• Protein 7%
• Enzyme Activity 7%
• Pharmacological Metabolism 6%
• Ammonia 6%
• Glucose 6%
• Nitrogen 5%
• Carbon Atom 4%
• Oxidation Reaction 3%
• Time 3%