TY - JOUR
T1 - Mature B-cell leukemias with more than 55% prolymphocytes
T2 - A heterogeneous group that includes an unusual variant of mantle cell lymphoma
AU - Schlette, Ellen
AU - Bueso-Ramos, Carlos
AU - Giles, Francis
AU - Glassman, Armand
AU - Hayes, Kimberly
AU - Medeiros, L. Jeffrey
PY - 2001/4
Y1 - 2001/4
N2 - We studied 20 cases of mature B-cell leukemia with more than 55% prolymphocytes in peripheral blood or bone marrow, fulfilling the French-American-British criteria for B-cell prolymphocytic leukemia (PLL). Cases segregated into 3 groups: de novo PLL, 6; PLL occurring in patients with a previous well-established diagnosis of chronic lymphocytic leukemia (PLL-HxCLL), 10; and t(11;14)(q13;q32)-positive neoplasms, 4. All cases expressed monotypic immunoglobulin light chain, and most were positive for CD5. All t(11;14)-positive neoplasms were CD23- and uniquely positive for cyclin D1. Cytogenetic abnormalities were present in 19; in all 19, the karyotype was complex, indicating clonal evolution and genomic instability. The most frequent cytogenetic abnormality in de novo PLL involved chromosome 7 in 4 cases. Trisomy 12 or add(12p) was present in 4 cases of PLL-HxCLL. We conclude that mature B-cell leukemias with more than 55% prolymphocytes are a heterogeneous group that includes t(11;14)-positive neoplasms, which we suggest are best classified as mantle cell lymphoma. We also suggest that prolymphocytic morphologic features are a common end-stage of transformation for several B-cell neoplasms.
AB - We studied 20 cases of mature B-cell leukemia with more than 55% prolymphocytes in peripheral blood or bone marrow, fulfilling the French-American-British criteria for B-cell prolymphocytic leukemia (PLL). Cases segregated into 3 groups: de novo PLL, 6; PLL occurring in patients with a previous well-established diagnosis of chronic lymphocytic leukemia (PLL-HxCLL), 10; and t(11;14)(q13;q32)-positive neoplasms, 4. All cases expressed monotypic immunoglobulin light chain, and most were positive for CD5. All t(11;14)-positive neoplasms were CD23- and uniquely positive for cyclin D1. Cytogenetic abnormalities were present in 19; in all 19, the karyotype was complex, indicating clonal evolution and genomic instability. The most frequent cytogenetic abnormality in de novo PLL involved chromosome 7 in 4 cases. Trisomy 12 or add(12p) was present in 4 cases of PLL-HxCLL. We conclude that mature B-cell leukemias with more than 55% prolymphocytes are a heterogeneous group that includes t(11;14)-positive neoplasms, which we suggest are best classified as mantle cell lymphoma. We also suggest that prolymphocytic morphologic features are a common end-stage of transformation for several B-cell neoplasms.
KW - Chronic lymphocytic leukemia
KW - Cyclin D1
KW - Immunophenotype
KW - Mantle cell lymphoma
KW - Prolymphocytic leukemia
KW - t(11;14)
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U2 - 10.1309/PPK0-TJUK-1UAR-3194
DO - 10.1309/PPK0-TJUK-1UAR-3194
M3 - Article
C2 - 11293906
AN - SCOPUS:0035057260
SN - 0002-9173
VL - 115
SP - 571
EP - 581
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 4
ER -