Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

Kensuke Kojima, Marina Konopleva, Teresa McQueen, Susan O'Brien, William Plunkett, Michael Andreeff

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206 Scopus citations

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Medicine & Life Sciences

Chemistry