TY - JOUR
T1 - Mechanism of action of the nitrosoureas
T2 - Formation of 1,2-(diguanosin-7-yl) ethane from the reaction of BCNU (1,3-bis-[2-chloroethyl]-1-nitrosourea) with guanosine
AU - Gombar, Charles T.
AU - Tong, William P.
AU - Ludlum, David B.
PY - 1979/10/12
Y1 - 1979/10/12
N2 - A crosslinked dinucleoside, 1,2-(diguanosin-7-yl) ethane, has been isolated from the reaction of guanosine with the antitumor agent, BCNU. The formation of this product suggests that DNA crosslinking, which may be responsible for the cytotoxicity of BCNU, could occur through such dinucleosides.
AB - A crosslinked dinucleoside, 1,2-(diguanosin-7-yl) ethane, has been isolated from the reaction of guanosine with the antitumor agent, BCNU. The formation of this product suggests that DNA crosslinking, which may be responsible for the cytotoxicity of BCNU, could occur through such dinucleosides.
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U2 - 10.1016/0006-291X(79)91909-0
DO - 10.1016/0006-291X(79)91909-0
M3 - Article
C2 - 508350
AN - SCOPUS:0018622809
SN - 0006-291X
VL - 90
SP - 878
EP - 882
JO - Biochemical and biophysical research communications
JF - Biochemical and biophysical research communications
IS - 3
ER -