Mechanisms of cancer metastasis

Maria Castaneda; Petra den Hollander; Nick A. Kuburich; Jeffrey M. Rosen; Sendurai A. Mani

doi:10.1016/j.semcancer.2022.10.006

Mechanisms of cancer metastasis

Maria Castaneda, Petra den Hollander, Nick A. Kuburich, Jeffrey M. Rosen, Sendurai A. Mani

Translational Molecular Pathology

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from metastatic disease. Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of new tumors in other parts of the body. Open questions, avenues for future research, and therapeutic approaches with the potential to prevent or inhibit metastasis through personalization to each patient's mutation and/or immune profile are also highlighted.

Original language	English (US)
Pages (from-to)	17-31
Number of pages	15
Journal	Seminars in cancer biology
Volume	87
DOIs	https://doi.org/10.1016/j.semcancer.2022.10.006
State	Published - Dec 2022

Keywords

Cancer metastasis
Epithelial-mesenchymal plasticity
Epithelial-mesenchymal transition
Extravasation
Invasion

ASJC Scopus subject areas

Cancer Research

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10.1016/j.semcancer.2022.10.006

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@article{f6e8249d1b60437a9418984bda2eab76,

title = "Mechanisms of cancer metastasis",

abstract = "Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from metastatic disease. Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of new tumors in other parts of the body. Open questions, avenues for future research, and therapeutic approaches with the potential to prevent or inhibit metastasis through personalization to each patient's mutation and/or immune profile are also highlighted.",

keywords = "Cancer metastasis, Epithelial-mesenchymal plasticity, Epithelial-mesenchymal transition, Extravasation, Invasion",

author = "Maria Castaneda and {den Hollander}, Petra and Kuburich, {Nick A.} and Rosen, {Jeffrey M.} and Mani, {Sendurai A.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = dec,

doi = "10.1016/j.semcancer.2022.10.006",

language = "English (US)",

volume = "87",

pages = "17--31",

journal = "Seminars in cancer biology",

issn = "1044-579X",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Mechanisms of cancer metastasis

AU - Castaneda, Maria

AU - den Hollander, Petra

AU - Kuburich, Nick A.

AU - Rosen, Jeffrey M.

AU - Mani, Sendurai A.

PY - 2022/12

Y1 - 2022/12

N2 - Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from metastatic disease. Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of new tumors in other parts of the body. Open questions, avenues for future research, and therapeutic approaches with the potential to prevent or inhibit metastasis through personalization to each patient's mutation and/or immune profile are also highlighted.

AB - Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from metastatic disease. Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of new tumors in other parts of the body. Open questions, avenues for future research, and therapeutic approaches with the potential to prevent or inhibit metastasis through personalization to each patient's mutation and/or immune profile are also highlighted.

KW - Cancer metastasis

KW - Epithelial-mesenchymal plasticity

KW - Epithelial-mesenchymal transition

KW - Extravasation

KW - Invasion

UR - http://www.scopus.com/inward/record.url?scp=85141382780&partnerID=8YFLogxK

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U2 - 10.1016/j.semcancer.2022.10.006

DO - 10.1016/j.semcancer.2022.10.006

M3 - Review article

C2 - 36354098

AN - SCOPUS:85141382780

SN - 1044-579X

VL - 87

SP - 17

EP - 31

JO - Seminars in cancer biology

JF - Seminars in cancer biology

ER -

Mechanisms of cancer metastasis

Abstract

Keywords

ASJC Scopus subject areas

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