Mechanoreciprocity in cell migration

Sjoerd Van Helvert; Cornelis Storm; Peter Friedl

doi:10.1038/s41556-017-0012-0

Mechanoreciprocity in cell migration

Sjoerd Van Helvert, Cornelis Storm, Peter Friedl

Genitourinary Medical Oncology

Research output: Contribution to journal › Review article › peer-review

367 Scopus citations

Abstract

Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.

Original language	English (US)
Pages (from-to)	8-20
Number of pages	13
Journal	Nature cell biology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1038/s41556-017-0012-0
State	Published - Jan 1 2018

ASJC Scopus subject areas

Cell Biology

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10.1038/s41556-017-0012-0

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abstract = "Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.",

author = "{Van Helvert}, Sjoerd and Cornelis Storm and Peter Friedl",

note = "Funding Information: We thank M. Zegers for proofreading the manuscript. The P.F. laboratory is supported by the European Research Council (617430-DEEPINSIGHT), NWO-Vici (918.11.626), Horizon 2020 consortium MULTIMOT (634107-2), the Cancer Genomics Center, (CGC.nl), NIH-U54 CA210184-01, the MD Anderson Cancer Center Moon Shot program and the Radboud Nanomedicine Alliance. C.S. was supported by funds from NWO-FOM (E1012M, E1009M, E1013M) and the TU/e Institute for Complex Molecular Systems. Publisher Copyright: {\textcopyright} Macmillan Publishers Ltd. part of Springer.",

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AU - Friedl, Peter

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N2 - Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.

AB - Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.

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Mechanoreciprocity in cell migration

Abstract

ASJC Scopus subject areas

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