Medical oncology management of hereditary colorectal cancer

Eduardo Vilar; Ramón Salazar; Josep Tabernero

doi:10.1007/978-3-319-74259-5_25

Medical oncology management of hereditary colorectal cancer

Eduardo Vilar, Ramón Salazar, Josep Tabernero

Clinical Cancer Prevention

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Hereditary colorectal cancer syndromes represent approximately 5% of the total of colorectal cancer cases. Although there are a myriad of diseases that are considered rare due to their frequency, there are two conditions that are common enough to be found in the daily medical oncology clinic: Lynch syndrome and Familial Adenomatous Polyposis. In this chapter, we will review the specific aspects of these two conditions from the medical oncology standpoint with particular emphasis to the use of systemic chemotherapy and targeted therapies for the treatment of these cases.

Original language	English (US)
Title of host publication	Hereditary Colorectal Cancer
Subtitle of host publication	Genetic Basis and Clinical Implications
Publisher	Springer International Publishing
Pages	401-413
Number of pages	13
ISBN (Electronic)	9783319742595
ISBN (Print)	9783319742588
DOIs	https://doi.org/10.1007/978-3-319-74259-5_25
State	Published - Jan 1 2018

Keywords

Chemotherapy
Colorectal cancer
Familial adenomatous polyposis
Immunotherapy
Lynch syndrome
Microsatellite instability

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-319-74259-5_25

Cite this

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AB - Hereditary colorectal cancer syndromes represent approximately 5% of the total of colorectal cancer cases. Although there are a myriad of diseases that are considered rare due to their frequency, there are two conditions that are common enough to be found in the daily medical oncology clinic: Lynch syndrome and Familial Adenomatous Polyposis. In this chapter, we will review the specific aspects of these two conditions from the medical oncology standpoint with particular emphasis to the use of systemic chemotherapy and targeted therapies for the treatment of these cases.

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KW - Immunotherapy

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KW - Microsatellite instability

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Medical oncology management of hereditary colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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