Medullary carcinoma: Clinical practice guidelines in oncology™

R. Michael Turtle; Douglas W. Ball; David Byrd; Gilbert H. Daniels; Raza A. Dilawari; Gerard M. Doherty; Quan Yang Duh; Hormoz Ehya; William B. Farrar; Robert I. Haddad; Fouad Kandeel; Richard T. Kloos; Peter Kopp; Dominick M. Lamonica; Thom R. Loree; William M. Lydiatt; Judith McCaffrey; John A. Olson; Lee Parks; John A. Ridge; Jatin P. Shah; Steven I. Sherman; Steven G. Waguespack; Thomas N. Wang; Lori J. Wirth

doi:10.6004/jnccn.2010.0040

Medullary carcinoma: Clinical practice guidelines in oncology™

R. Michael Turtle, Douglas W. Ball, David Byrd, Gilbert H. Daniels, Raza A. Dilawari, Gerard M. Doherty, Quan Yang Duh, Hormoz Ehya, William B. Farrar, Robert I. Haddad, Fouad Kandeel, Richard T. Kloos, Peter Kopp, Dominick M. Lamonica, Thom R. Loree, William M. Lydiatt, Judith McCaffrey, John A. Olson, Lee Parks, John A. RidgeJatin P. Shah, Steven I. Sherman, Steven G. Waguespack, Thomas N. Wang, Lori J. Wirth

Endocrine Neoplasia & HD

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on medullary thyroid carcinoma (MTC). NCCN Guidelines addressing papillarc follicular, HOrthle cell, and anaplastic thyroid carcinomas will appear in a later issue of JNCCN. Sporadic MTC accounts for approximately 80% of all cases of the disease. Sporadic disease typically presents in the fifth or sixth decade. Familial forms of the disease tend to present at earlier ages. Because the C cells are predominantly located in the upper portion of each thyroid lobe, patients with sporadic disease typically present with upper pole thyroid nodules. Metastatic cervical adenopathy appears in approximately 50% of patients at initial presentation. Symptoms of upper aerodigestive tract compression or invasion are reported by up to 15% of patients with sporadic disease. Symptoms from distant metastases in lungs or bones occur in 5% to 10% of patients. The risk for concomitant or subsequent development of pheochromocytoma and hyperparathyroidism must always be considered.

Original language	English (US)
Pages (from-to)	512-530
Number of pages	19
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	8
Issue number	5
DOIs	https://doi.org/10.6004/jnccn.2010.0040
State	Published - May 2010

Keywords

Cancer
External beam irradiation
Malignancy
Medullary thyroid cancer
NCCN clinical practice guidelines
Radiation therapy
Thyroid gland
Thyroidectomy
Tumor

ASJC Scopus subject areas

Oncology

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10.6004/jnccn.2010.0040

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Michael Turtle, R., Ball, D. W., Byrd, D., Daniels, G. H., Dilawari, R. A., Doherty, G. M., Duh, Q. Y., Ehya, H., Farrar, W. B., Haddad, R. I., Kandeel, F., Kloos, R. T., Kopp, P., Lamonica, D. M., Loree, T. R., Lydiatt, W. M., McCaffrey, J., Olson, J. A., Parks, L., ... Wirth, L. J. (2010). Medullary carcinoma: Clinical practice guidelines in oncology™. JNCCN Journal of the National Comprehensive Cancer Network, 8(5), 512-530. https://doi.org/10.6004/jnccn.2010.0040

Michael Turtle, R, Ball, DW, Byrd, D, Daniels, GH, Dilawari, RA, Doherty, GM, Duh, QY, Ehya, H, Farrar, WB, Haddad, RI, Kandeel, F, Kloos, RT, Kopp, P, Lamonica, DM, Loree, TR, Lydiatt, WM, McCaffrey, J, Olson, JA, Parks, L, Ridge, JA, Shah, JP, Sherman, SI , Waguespack, SG, Wang, TN & Wirth, LJ 2010, 'Medullary carcinoma: Clinical practice guidelines in oncology™', JNCCN Journal of the National Comprehensive Cancer Network, vol. 8, no. 5, pp. 512-530. https://doi.org/10.6004/jnccn.2010.0040

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abstract = "These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on medullary thyroid carcinoma (MTC). NCCN Guidelines addressing papillarc follicular, HOrthle cell, and anaplastic thyroid carcinomas will appear in a later issue of JNCCN. Sporadic MTC accounts for approximately 80% of all cases of the disease. Sporadic disease typically presents in the fifth or sixth decade. Familial forms of the disease tend to present at earlier ages. Because the C cells are predominantly located in the upper portion of each thyroid lobe, patients with sporadic disease typically present with upper pole thyroid nodules. Metastatic cervical adenopathy appears in approximately 50% of patients at initial presentation. Symptoms of upper aerodigestive tract compression or invasion are reported by up to 15% of patients with sporadic disease. Symptoms from distant metastases in lungs or bones occur in 5% to 10% of patients. The risk for concomitant or subsequent development of pheochromocytoma and hyperparathyroidism must always be considered.",

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Medullary carcinoma: Clinical practice guidelines in oncology™

Abstract

Keywords

ASJC Scopus subject areas

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