Meeting report: High-throughput technologies for in vivo imaging agents

Robert J. Gillies; John M. Hoffman; Kit S. Lam; Anne E. Menkens; David R. Piwnica-Worms; Daniel C. Sullivan; Ralph Weissleder

Meeting report: High-throughput technologies for in vivo imaging agents

Robert J. Gillies, John M. Hoffman, Kit S. Lam, Anne E. Menkens, David R. Piwnica-Worms, Daniel C. Sullivan, Ralph Weissleder

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Combinatorial chemistry and high-throughput screening have become standard tools for discovering new drug candidates with suitable pharmacological properties. Now, those same technologies are starting to be applied to the problem of discovering novel in vivo imaging agents. Important differences in the biological and pharmacological properties needed for imaging agents, compared to those for a therapeutic agent, require new screening methods that emphasize those characteristics, such as optimized residence time and tissue specificity, that make for a good imaging agent candidate.

Original language	English (US)
Pages (from-to)	98-103
Number of pages	6
Journal	Molecular imaging
Volume	4
Issue number	2
State	Published - Apr 2005
Externally published	Yes

Keywords

Combinatorial chemistry
High-throughput assays
Imaging agent libraries
Informatics
Screening models

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Biomedical Engineering
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

Cite this

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title = "Meeting report: High-throughput technologies for in vivo imaging agents",

abstract = "Combinatorial chemistry and high-throughput screening have become standard tools for discovering new drug candidates with suitable pharmacological properties. Now, those same technologies are starting to be applied to the problem of discovering novel in vivo imaging agents. Important differences in the biological and pharmacological properties needed for imaging agents, compared to those for a therapeutic agent, require new screening methods that emphasize those characteristics, such as optimized residence time and tissue specificity, that make for a good imaging agent candidate.",

keywords = "Combinatorial chemistry, High-throughput assays, Imaging agent libraries, Informatics, Screening models",

author = "Gillies, {Robert J.} and Hoffman, {John M.} and Lam, {Kit S.} and Menkens, {Anne E.} and Piwnica-Worms, {David R.} and Sullivan, {Daniel C.} and Ralph Weissleder",

year = "2005",

month = apr,

language = "English (US)",

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pages = "98--103",

journal = "Molecular imaging",

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AU - Gillies, Robert J.

AU - Hoffman, John M.

AU - Lam, Kit S.

AU - Menkens, Anne E.

AU - Piwnica-Worms, David R.

AU - Sullivan, Daniel C.

AU - Weissleder, Ralph

PY - 2005/4

Y1 - 2005/4

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AB - Combinatorial chemistry and high-throughput screening have become standard tools for discovering new drug candidates with suitable pharmacological properties. Now, those same technologies are starting to be applied to the problem of discovering novel in vivo imaging agents. Important differences in the biological and pharmacological properties needed for imaging agents, compared to those for a therapeutic agent, require new screening methods that emphasize those characteristics, such as optimized residence time and tissue specificity, that make for a good imaging agent candidate.

KW - Combinatorial chemistry

KW - High-throughput assays

KW - Imaging agent libraries

KW - Informatics

KW - Screening models

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ER -

Meeting report: High-throughput technologies for in vivo imaging agents

Abstract

Keywords

ASJC Scopus subject areas

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