Melanoma Brain Metastasis: Insights, Progress, Challenges, and Opportunities

Grant M. Fischer; Michael A. Davies

doi:10.1007/978-1-4614-7147-9_44

Melanoma Brain Metastasis: Insights, Progress, Challenges, and Opportunities

Grant M. Fischer, Michael A. Davies

Melanoma Medical Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Brain metastasis is a frequent and often devastating complication of metastatic melanoma. Melanoma has one of the highest rates of brain metastasis among all solid tumors. Historically the survival for melanoma patients with brain metastases has been less than 6 months. However, the development of improved CNS-directed and systemic therapies appears to be resulting in rapidly improving outcomes in these patients. In parallel, there is growing understanding of the unique features of brain metastases that contribute to their aggressive behavior, providing new opportunities to develop additional strategies to further improve patient outcomes. This chapter will review the current understanding of the pathogenesis of melanoma brain metastases and the treatments used for this disease to provide a context for future investigations in this area.

Original language	English (US)
Title of host publication	Melanoma
Publisher	Springer New York
Pages	535-555
Number of pages	21
ISBN (Electronic)	9781461471479
ISBN (Print)	9781461471462
DOIs	https://doi.org/10.1007/978-1-4614-7147-9_44
State	Published - Jan 1 2019

Keywords

Brain metastasis
Immunotherapy
Melanoma
Stereotactic radiosurgery
Targeted therapy
Whole brain radiation therapy

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-7147-9_44

Cite this

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abstract = "Brain metastasis is a frequent and often devastating complication of metastatic melanoma. Melanoma has one of the highest rates of brain metastasis among all solid tumors. Historically the survival for melanoma patients with brain metastases has been less than 6 months. However, the development of improved CNS-directed and systemic therapies appears to be resulting in rapidly improving outcomes in these patients. In parallel, there is growing understanding of the unique features of brain metastases that contribute to their aggressive behavior, providing new opportunities to develop additional strategies to further improve patient outcomes. This chapter will review the current understanding of the pathogenesis of melanoma brain metastases and the treatments used for this disease to provide a context for future investigations in this area.",

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AB - Brain metastasis is a frequent and often devastating complication of metastatic melanoma. Melanoma has one of the highest rates of brain metastasis among all solid tumors. Historically the survival for melanoma patients with brain metastases has been less than 6 months. However, the development of improved CNS-directed and systemic therapies appears to be resulting in rapidly improving outcomes in these patients. In parallel, there is growing understanding of the unique features of brain metastases that contribute to their aggressive behavior, providing new opportunities to develop additional strategies to further improve patient outcomes. This chapter will review the current understanding of the pathogenesis of melanoma brain metastases and the treatments used for this disease to provide a context for future investigations in this area.

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KW - Stereotactic radiosurgery

KW - Targeted therapy

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Melanoma Brain Metastasis: Insights, Progress, Challenges, and Opportunities

Abstract

Keywords

ASJC Scopus subject areas

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