Melanoma central nervous system metastases: current approaches, challenges, and opportunities

Justine V. Cohen; Hussain Tawbi; Kim A. Margolin; Ravi Amravadi; Marcus Bosenberg; Priscilla K. Brastianos; Veronica L. Chiang; John de Groot; Isabella C. Glitza; Meenhard Herlyn; Sheri L. Holmen; Lucia B. Jilaveanu; Andrew Lassman; Stergios Moschos; Michael A. Postow; Reena Thomas; John A. Tsiouris; Patrick Wen; Richard M. White; Timothy Turnham; Michael A. Davies; Harriet M. Kluger

doi:10.1111/pcmr.12538

Melanoma central nervous system metastases: current approaches, challenges, and opportunities

Justine V. Cohen, Hussain Tawbi, Kim A. Margolin, Ravi Amravadi, Marcus Bosenberg, Priscilla K. Brastianos, Veronica L. Chiang, John de Groot, Isabella C. Glitza, Meenhard Herlyn, Sheri L. Holmen, Lucia B. Jilaveanu, Andrew Lassman, Stergios Moschos, Michael A. Postow, Reena Thomas, John A. Tsiouris, Patrick Wen, Richard M. White, Timothy TurnhamMichael A. Davies, Harriet M. Kluger

Research output: Contribution to journal › Review article › peer-review

90 Scopus citations

Abstract

Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.

Original language	English (US)
Pages (from-to)	627-642
Number of pages	16
Journal	Pigment Cell and Melanoma Research
Volume	29
Issue number	6
DOIs	https://doi.org/10.1111/pcmr.12538
State	Published - Nov 1 2016

Keywords

brain metastasis
clinical trials
experimental models
leptomeningeal disease
tumor microenvironment

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Oncology
Dermatology

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10.1111/pcmr.12538

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Cohen, J. V., Tawbi, H., Margolin, K. A., Amravadi, R., Bosenberg, M., Brastianos, P. K., Chiang, V. L., de Groot, J., Glitza, I. C., Herlyn, M., Holmen, S. L., Jilaveanu, L. B., Lassman, A., Moschos, S., Postow, M. A., Thomas, R., Tsiouris, J. A., Wen, P., White, R. M., ... Kluger, H. M. (2016). Melanoma central nervous system metastases: current approaches, challenges, and opportunities. Pigment Cell and Melanoma Research, 29(6), 627-642. https://doi.org/10.1111/pcmr.12538

Cohen, JV, Tawbi, H, Margolin, KA, Amravadi, R, Bosenberg, M, Brastianos, PK, Chiang, VL, de Groot, J, Glitza, IC, Herlyn, M, Holmen, SL, Jilaveanu, LB, Lassman, A, Moschos, S, Postow, MA, Thomas, R, Tsiouris, JA, Wen, P, White, RM, Turnham, T, Davies, MA & Kluger, HM 2016, 'Melanoma central nervous system metastases: current approaches, challenges, and opportunities', Pigment Cell and Melanoma Research, vol. 29, no. 6, pp. 627-642. https://doi.org/10.1111/pcmr.12538

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title = "Melanoma central nervous system metastases: current approaches, challenges, and opportunities",

abstract = "Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.",

keywords = "brain metastasis, clinical trials, experimental models, leptomeningeal disease, tumor microenvironment",

author = "Cohen, {Justine V.} and Hussain Tawbi and Margolin, {Kim A.} and Ravi Amravadi and Marcus Bosenberg and Brastianos, {Priscilla K.} and Chiang, {Veronica L.} and {de Groot}, John and Glitza, {Isabella C.} and Meenhard Herlyn and Holmen, {Sheri L.} and Jilaveanu, {Lucia B.} and Andrew Lassman and Stergios Moschos and Postow, {Michael A.} and Reena Thomas and Tsiouris, {John A.} and Patrick Wen and White, {Richard M.} and Timothy Turnham and Davies, {Michael A.} and Kluger, {Harriet M.}",

note = "Publisher Copyright: {\textcopyright} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2016",

month = nov,

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doi = "10.1111/pcmr.12538",

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T2 - current approaches, challenges, and opportunities

AU - Cohen, Justine V.

AU - Tawbi, Hussain

AU - Margolin, Kim A.

AU - Amravadi, Ravi

AU - Bosenberg, Marcus

AU - Brastianos, Priscilla K.

AU - Chiang, Veronica L.

AU - de Groot, John

AU - Glitza, Isabella C.

AU - Herlyn, Meenhard

AU - Holmen, Sheri L.

AU - Jilaveanu, Lucia B.

AU - Lassman, Andrew

AU - Moschos, Stergios

AU - Postow, Michael A.

AU - Thomas, Reena

AU - Tsiouris, John A.

AU - Wen, Patrick

AU - White, Richard M.

AU - Turnham, Timothy

AU - Davies, Michael A.

AU - Kluger, Harriet M.

PY - 2016/11/1

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N2 - Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.

AB - Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.

KW - brain metastasis

KW - clinical trials

KW - experimental models

KW - leptomeningeal disease

KW - tumor microenvironment

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Melanoma central nervous system metastases: current approaches, challenges, and opportunities

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Keywords

ASJC Scopus subject areas

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