Melanoma metastatic to cervical lymph nodes: Can radiotherapy replace formal dissection after local excision of nodal disease?

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38 Citations (Scopus)

Abstract

Background. Completion cervical lymphadenectomy is usually performed after excisional biopsy of nodal metastases from melanoma. Radiation (XRT) might be effective for some patients in lieu of formal lymph node dissection. Methods. Thirty-six patients with parotid or cervical node metastases from melanoma were treated with excision of nodal disease and postoperative XRT without formal lymph node dissection. Radiation was delivered to the primary site (if known), the site of nodal excision, and the undissected ipsilateral neck. Results. With a median follow-up of 5.3 years, the disease recurred within the regional basin in two patients and at distant sites in 14 patients. The actuarial 5-year regional contre and distant metastasis-free survival rates were 93% and 59%, respectively. Two patients had a clinically significant side effect develop. Conclusions. The results of this study suggest that selected patients may receive regional XRT after local excision of nodal disease from melanoma in lieu of formal lymph node dissection.

Original languageEnglish (US)
Pages (from-to)718-721
Number of pages4
JournalHead and Neck
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2005

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Dissection
Melanoma
Radiotherapy
Lymph Nodes
Lymph Node Excision
Neoplasm Metastasis
Radiation
Neck
Survival Rate
Biopsy

Keywords

  • Melanoma
  • Radiation
  • Surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{1cb2306d1c024db29855ea985485deca,
title = "Melanoma metastatic to cervical lymph nodes: Can radiotherapy replace formal dissection after local excision of nodal disease?",
abstract = "Background. Completion cervical lymphadenectomy is usually performed after excisional biopsy of nodal metastases from melanoma. Radiation (XRT) might be effective for some patients in lieu of formal lymph node dissection. Methods. Thirty-six patients with parotid or cervical node metastases from melanoma were treated with excision of nodal disease and postoperative XRT without formal lymph node dissection. Radiation was delivered to the primary site (if known), the site of nodal excision, and the undissected ipsilateral neck. Results. With a median follow-up of 5.3 years, the disease recurred within the regional basin in two patients and at distant sites in 14 patients. The actuarial 5-year regional contre and distant metastasis-free survival rates were 93{\%} and 59{\%}, respectively. Two patients had a clinically significant side effect develop. Conclusions. The results of this study suggest that selected patients may receive regional XRT after local excision of nodal disease from melanoma in lieu of formal lymph node dissection.",
keywords = "Melanoma, Radiation, Surgery",
author = "Ballo, {Matthew T.} and Garden, {Adam S} and Myers, {Jeffrey N} and Lee, {Jeffrey E} and {Diaz Jr}, {Eduardo M} and Sturgis, {Erich M} and Morrison, {William H} and Gershenwald, {Jeffrey E} and Ross, {Merrick I} and Weber, {Randal S} and Ang, {K. Kian}",
year = "2005",
month = "8",
day = "1",
doi = "10.1002/hed.20233",
language = "English (US)",
volume = "27",
pages = "718--721",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley-Liss Inc.",
number = "8",

}

TY - JOUR

T1 - Melanoma metastatic to cervical lymph nodes

T2 - Can radiotherapy replace formal dissection after local excision of nodal disease?

AU - Ballo, Matthew T.

AU - Garden, Adam S

AU - Myers, Jeffrey N

AU - Lee, Jeffrey E

AU - Diaz Jr, Eduardo M

AU - Sturgis, Erich M

AU - Morrison, William H

AU - Gershenwald, Jeffrey E

AU - Ross, Merrick I

AU - Weber, Randal S

AU - Ang, K. Kian

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Background. Completion cervical lymphadenectomy is usually performed after excisional biopsy of nodal metastases from melanoma. Radiation (XRT) might be effective for some patients in lieu of formal lymph node dissection. Methods. Thirty-six patients with parotid or cervical node metastases from melanoma were treated with excision of nodal disease and postoperative XRT without formal lymph node dissection. Radiation was delivered to the primary site (if known), the site of nodal excision, and the undissected ipsilateral neck. Results. With a median follow-up of 5.3 years, the disease recurred within the regional basin in two patients and at distant sites in 14 patients. The actuarial 5-year regional contre and distant metastasis-free survival rates were 93% and 59%, respectively. Two patients had a clinically significant side effect develop. Conclusions. The results of this study suggest that selected patients may receive regional XRT after local excision of nodal disease from melanoma in lieu of formal lymph node dissection.

AB - Background. Completion cervical lymphadenectomy is usually performed after excisional biopsy of nodal metastases from melanoma. Radiation (XRT) might be effective for some patients in lieu of formal lymph node dissection. Methods. Thirty-six patients with parotid or cervical node metastases from melanoma were treated with excision of nodal disease and postoperative XRT without formal lymph node dissection. Radiation was delivered to the primary site (if known), the site of nodal excision, and the undissected ipsilateral neck. Results. With a median follow-up of 5.3 years, the disease recurred within the regional basin in two patients and at distant sites in 14 patients. The actuarial 5-year regional contre and distant metastasis-free survival rates were 93% and 59%, respectively. Two patients had a clinically significant side effect develop. Conclusions. The results of this study suggest that selected patients may receive regional XRT after local excision of nodal disease from melanoma in lieu of formal lymph node dissection.

KW - Melanoma

KW - Radiation

KW - Surgery

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U2 - 10.1002/hed.20233

DO - 10.1002/hed.20233

M3 - Review article

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SP - 718

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JO - Head and Neck

JF - Head and Neck

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