Abstract
With the increasing utility of hematopoietic stem cell transplantation (SCT) as a treatment for cancer and noncancerous disorders, more challenges and complications associated with SCT have emerged. Renal injury immediately after transplant is common and well understood, but long-termrenal injury is becoming more evident. Chronic graft-versus-host disease (GVHD) is a known long-term complication of SCT, and membranous nephropathy (MN) is emerging as the most common cause of SCTassociated glomerular pathology. In this case report, we present a patient who developed features of anti-PLA2R antibodynegative MN following autologous SCT. The renal injury responded well to steroids and further response to rituximab therapy was noted, suggesting antibody-mediated autoimmune glomerular disease. We also present a review of the literature on autologous GVHD and the role of T and B cells in induction of autoimmunity by SCT.
Original language | English (US) |
---|---|
Pages (from-to) | 440-444 |
Number of pages | 5 |
Journal | Clinical Kidney Journal |
Volume | 8 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2015 |
Keywords
- Anti-PLA2R
- Autologous stem cell transplant
- GVHD
- Membranous nephropathy
ASJC Scopus subject areas
- Nephrology
- Transplantation