Mesenchymal stem cell treatment for ischemic brain injury

Cindy T.J. van Velthoven; Annemieke Kavelaars; Cobi J. Heijnen

doi:10.1007/978-94-007-2900-1_7

Mesenchymal stem cell treatment for ischemic brain injury

Cindy T.J. van Velthoven, Annemieke Kavelaars, Cobi J. Heijnen

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cell-based therapies for experimental models of neonatal and adult ischemic brain injury are effective for repairing the damaged brain. Transplantation of mesenchymal stem cells does not only replace lost tissue, but more importantly also enhances repair processes in the brain. The induction of processes like neurogenesis, angiogenesis and axonal remodeling likely underlie the improved functional outcome. These repair processes are mediated via many growth factors secreted by transplanted stem cells and parenchymal cells. After transplantation, mesenchymal stem cells react to the ischemic cerebral environment and change their secretory profile to the need of the cerebral environment. The interplay between transplanted mesenchymal stem cells and parenchymal cells will ultimately define the extent of repair.

Original language	English (US)
Title of host publication	Stem Cells and Cancer Stem Cells, Volume 5
Subtitle of host publication	Therapeutic Applications in Disease and Injury
Publisher	Springer Netherlands
Pages	73-83
Number of pages	11
ISBN (Electronic)	9789400729001
ISBN (Print)	9789400728998
DOIs	https://doi.org/10.1007/978-94-007-2900-1_7
State	Published - Jan 1 2012
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1007/978-94-007-2900-1_7

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abstract = "Cell-based therapies for experimental models of neonatal and adult ischemic brain injury are effective for repairing the damaged brain. Transplantation of mesenchymal stem cells does not only replace lost tissue, but more importantly also enhances repair processes in the brain. The induction of processes like neurogenesis, angiogenesis and axonal remodeling likely underlie the improved functional outcome. These repair processes are mediated via many growth factors secreted by transplanted stem cells and parenchymal cells. After transplantation, mesenchymal stem cells react to the ischemic cerebral environment and change their secretory profile to the need of the cerebral environment. The interplay between transplanted mesenchymal stem cells and parenchymal cells will ultimately define the extent of repair.",

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AB - Cell-based therapies for experimental models of neonatal and adult ischemic brain injury are effective for repairing the damaged brain. Transplantation of mesenchymal stem cells does not only replace lost tissue, but more importantly also enhances repair processes in the brain. The induction of processes like neurogenesis, angiogenesis and axonal remodeling likely underlie the improved functional outcome. These repair processes are mediated via many growth factors secreted by transplanted stem cells and parenchymal cells. After transplantation, mesenchymal stem cells react to the ischemic cerebral environment and change their secretory profile to the need of the cerebral environment. The interplay between transplanted mesenchymal stem cells and parenchymal cells will ultimately define the extent of repair.

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Mesenchymal stem cell treatment for ischemic brain injury

Abstract

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