Mesenchymal to epithelial transition in sarcomas

Jilong Yang; Xiaoling Du; Guowen Wang; Yan Sun; Kexin Chen; Xiongzeng Zhu; Alexander J.F. Lazar; Kelly K. Hunt; Raphael E. Pollock; Wei Zhang

doi:10.1016/j.ejca.2013.11.006

Mesenchymal to epithelial transition in sarcomas

Jilong Yang, Xiaoling Du, Guowen Wang, Yan Sun, Kexin Chen, Xiongzeng Zhu, Alexander J.F. Lazar, Kelly K. Hunt, Raphael E. Pollock, Wei Zhang

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Mesenchymal to epithelial transition (MET) in carcinomas has been proposed to promote the growth of epithelial tumour cells at distant sites during metastasis. MET has also been suggested as an important biological and clinical process in mesenchymal tumors, sarcomas. Here we review studies on MET in sarcomas, including molecular markers, signalling mechanisms, regulation by micro RNAs and therapeutic implications. Accumulating evidences suggest that deeper investigation and understanding of MET in sarcomas would shed light on the pathogenesis of sarcomas and might lead to identification of potential clinical biomarkers for prognosis and targets for sarcoma therapeutics.

Original language	English (US)
Pages (from-to)	593-601
Number of pages	9
Journal	European Journal of Cancer
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.ejca.2013.11.006
State	Published - Feb 2014

Keywords

E-cadherin
Epithelial differentiation
Mesenchymal to epithelial transition
Micro RNA
Sarcoma
Targeted therapy
Transcriptional factors

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/j.ejca.2013.11.006

Cite this

@article{a92c63cec77841878a22205ec031d53d,

title = "Mesenchymal to epithelial transition in sarcomas",

abstract = "Mesenchymal to epithelial transition (MET) in carcinomas has been proposed to promote the growth of epithelial tumour cells at distant sites during metastasis. MET has also been suggested as an important biological and clinical process in mesenchymal tumors, sarcomas. Here we review studies on MET in sarcomas, including molecular markers, signalling mechanisms, regulation by micro RNAs and therapeutic implications. Accumulating evidences suggest that deeper investigation and understanding of MET in sarcomas would shed light on the pathogenesis of sarcomas and might lead to identification of potential clinical biomarkers for prognosis and targets for sarcoma therapeutics.",

keywords = "E-cadherin, Epithelial differentiation, Mesenchymal to epithelial transition, Micro RNA, Sarcoma, Targeted therapy, Transcriptional factors",

author = "Jilong Yang and Xiaoling Du and Guowen Wang and Yan Sun and Kexin Chen and Xiongzeng Zhu and Lazar, {Alexander J.F.} and Hunt, {Kelly K.} and Pollock, {Raphael E.} and Wei Zhang",

note = "Funding Information: This work was partly supported by the National Nature Science Foundation of China (81372872 to J.Y. and 81320108022 to K.C.), the funds from the University Cancer Foundation via the Sister Institution Network Fund (SINF) at the Tianjin Medical University Cancer Institute & Hospital, the Fudan University Shanghai Cancer Center and The University of Texas MD Anderson Cancer Center. This work was also partly supported by the Program for Changjiang Scholars and Innovative Research Team in the University (PCSIRT) in China (IRT1076) and the National Key Scientific and Technological Project (2011ZX09307-001-04) (K. Chen). ",

year = "2014",

month = feb,

doi = "10.1016/j.ejca.2013.11.006",

language = "English (US)",

volume = "50",

pages = "593--601",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Mesenchymal to epithelial transition in sarcomas

AU - Yang, Jilong

AU - Du, Xiaoling

AU - Wang, Guowen

AU - Sun, Yan

AU - Chen, Kexin

AU - Zhu, Xiongzeng

AU - Lazar, Alexander J.F.

AU - Hunt, Kelly K.

AU - Pollock, Raphael E.

AU - Zhang, Wei

N1 - Funding Information: This work was partly supported by the National Nature Science Foundation of China (81372872 to J.Y. and 81320108022 to K.C.), the funds from the University Cancer Foundation via the Sister Institution Network Fund (SINF) at the Tianjin Medical University Cancer Institute & Hospital, the Fudan University Shanghai Cancer Center and The University of Texas MD Anderson Cancer Center. This work was also partly supported by the Program for Changjiang Scholars and Innovative Research Team in the University (PCSIRT) in China (IRT1076) and the National Key Scientific and Technological Project (2011ZX09307-001-04) (K. Chen).

PY - 2014/2

Y1 - 2014/2

N2 - Mesenchymal to epithelial transition (MET) in carcinomas has been proposed to promote the growth of epithelial tumour cells at distant sites during metastasis. MET has also been suggested as an important biological and clinical process in mesenchymal tumors, sarcomas. Here we review studies on MET in sarcomas, including molecular markers, signalling mechanisms, regulation by micro RNAs and therapeutic implications. Accumulating evidences suggest that deeper investigation and understanding of MET in sarcomas would shed light on the pathogenesis of sarcomas and might lead to identification of potential clinical biomarkers for prognosis and targets for sarcoma therapeutics.

AB - Mesenchymal to epithelial transition (MET) in carcinomas has been proposed to promote the growth of epithelial tumour cells at distant sites during metastasis. MET has also been suggested as an important biological and clinical process in mesenchymal tumors, sarcomas. Here we review studies on MET in sarcomas, including molecular markers, signalling mechanisms, regulation by micro RNAs and therapeutic implications. Accumulating evidences suggest that deeper investigation and understanding of MET in sarcomas would shed light on the pathogenesis of sarcomas and might lead to identification of potential clinical biomarkers for prognosis and targets for sarcoma therapeutics.

KW - E-cadherin

KW - Epithelial differentiation

KW - Mesenchymal to epithelial transition

KW - Micro RNA

KW - Sarcoma

KW - Targeted therapy

KW - Transcriptional factors

UR - http://www.scopus.com/inward/record.url?scp=84893665051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893665051&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2013.11.006

DO - 10.1016/j.ejca.2013.11.006

M3 - Article

C2 - 24291235

AN - SCOPUS:84893665051

SN - 0959-8049

VL - 50

SP - 593

EP - 601

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 3

ER -

Mesenchymal to epithelial transition in sarcomas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this