Mesenchymal to epithelial transition in sarcomas

Jilong Yang, Xiaoling Du, Guowen Wang, Yan Sun, Kexin Chen, Xiongzeng Zhu, Alexander J.F. Lazar, Kelly K. Hunt, Raphael E. Pollock, Wei Zhang

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Mesenchymal to epithelial transition (MET) in carcinomas has been proposed to promote the growth of epithelial tumour cells at distant sites during metastasis. MET has also been suggested as an important biological and clinical process in mesenchymal tumors, sarcomas. Here we review studies on MET in sarcomas, including molecular markers, signalling mechanisms, regulation by micro RNAs and therapeutic implications. Accumulating evidences suggest that deeper investigation and understanding of MET in sarcomas would shed light on the pathogenesis of sarcomas and might lead to identification of potential clinical biomarkers for prognosis and targets for sarcoma therapeutics.

Original languageEnglish (US)
Pages (from-to)593-601
Number of pages9
JournalEuropean Journal of Cancer
Volume50
Issue number3
DOIs
StatePublished - Feb 1 2014

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Keywords

  • E-cadherin
  • Epithelial differentiation
  • Mesenchymal to epithelial transition
  • Micro RNA
  • Sarcoma
  • Targeted therapy
  • Transcriptional factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Yang, J., Du, X., Wang, G., Sun, Y., Chen, K., Zhu, X., Lazar, A. J. F., Hunt, K. K., Pollock, R. E., & Zhang, W. (2014). Mesenchymal to epithelial transition in sarcomas. European Journal of Cancer, 50(3), 593-601. https://doi.org/10.1016/j.ejca.2013.11.006