Metabolic imaging as a biomarker of early radiation response in tumors

Stephen Y. Lai; C. David Fuller; Pratip K. Bhattacharya; Steven J. Frank

doi:10.1158/1078-0432.CCR-15-1214

Metabolic imaging as a biomarker of early radiation response in tumors

Stephen Y. Lai, C. David Fuller, Pratip K. Bhattacharya, Steven J. Frank

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

¹³C-pyruvate hyperpolarized magnetic resonance imaging (HP-MRI) is emerging as a viable quantitative biomarker for solid tumor response and normal tissue toxicity after radiotherapy. This technology effectively predicts response related to metabolic agents or alterations in the tumor microenvironment, but challenges remain to be addressed to ensure successful translational implementation.

Original language	English (US)
Pages (from-to)	4996-4998
Number of pages	3
Journal	Clinical Cancer Research
Volume	21
Issue number	22
DOIs	https://doi.org/10.1158/1078-0432.CCR-15-1214
State	Published - Nov 15 2015

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Metabolic imaging as a biomarker of early radiation response in tumors",

abstract = "13C-pyruvate hyperpolarized magnetic resonance imaging (HP-MRI) is emerging as a viable quantitative biomarker for solid tumor response and normal tissue toxicity after radiotherapy. This technology effectively predicts response related to metabolic agents or alterations in the tumor microenvironment, but challenges remain to be addressed to ensure successful translational implementation.",

author = "Lai, {Stephen Y.} and Fuller, {C. David} and Bhattacharya, {Pratip K.} and Frank, {Steven J.}",

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AU - Lai, Stephen Y.

AU - Fuller, C. David

AU - Bhattacharya, Pratip K.

AU - Frank, Steven J.

PY - 2015/11/15

Y1 - 2015/11/15

N2 - 13C-pyruvate hyperpolarized magnetic resonance imaging (HP-MRI) is emerging as a viable quantitative biomarker for solid tumor response and normal tissue toxicity after radiotherapy. This technology effectively predicts response related to metabolic agents or alterations in the tumor microenvironment, but challenges remain to be addressed to ensure successful translational implementation.

AB - 13C-pyruvate hyperpolarized magnetic resonance imaging (HP-MRI) is emerging as a viable quantitative biomarker for solid tumor response and normal tissue toxicity after radiotherapy. This technology effectively predicts response related to metabolic agents or alterations in the tumor microenvironment, but challenges remain to be addressed to ensure successful translational implementation.

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DO - 10.1158/1078-0432.CCR-15-1214

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C2 - 26232369

AN - SCOPUS:84957580229

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SP - 4996

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JO - Clinical Cancer Research

JF - Clinical Cancer Research

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Metabolic imaging as a biomarker of early radiation response in tumors

Abstract

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