TY - JOUR
T1 - Metabolism and action of purine nucleoside analogs
AU - Plunkett, William
AU - Saunders, Priscilla P.
PY - 1991
Y1 - 1991
N2 - Recent investigations have identified many new purine nucleoside analogs that act as antimetabolites. This article focuses on the metabolism and mechanisms of action of tiazofurin, 3-deazaguanosine, neplanocin A, arabinosyladenine in combination with inhibitors of adenosine deaminase, arabinosyl-2-fluoroadenine, and 2-chloro-2′-deoxyadenosine, drugs that are either currently being evaluated in clinical trials or are close to that stage. The diverse metabolic requirements for activation, unique mechanisms of action, and differential biological activities of these compounds are characterized and evaluated for prospective therapeutic application.
AB - Recent investigations have identified many new purine nucleoside analogs that act as antimetabolites. This article focuses on the metabolism and mechanisms of action of tiazofurin, 3-deazaguanosine, neplanocin A, arabinosyladenine in combination with inhibitors of adenosine deaminase, arabinosyl-2-fluoroadenine, and 2-chloro-2′-deoxyadenosine, drugs that are either currently being evaluated in clinical trials or are close to that stage. The diverse metabolic requirements for activation, unique mechanisms of action, and differential biological activities of these compounds are characterized and evaluated for prospective therapeutic application.
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U2 - 10.1016/0163-7258(91)90057-S
DO - 10.1016/0163-7258(91)90057-S
M3 - Review article
C2 - 1675805
AN - SCOPUS:0025890427
SN - 0163-7258
VL - 49
SP - 239
EP - 268
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 3
ER -