Metabolism of tiazofurin by human erythrocytes and mononuclear blood cells in vitro

John D. Roberts; William P. Tong; Jeanette N. Hartshorn; Miles P. Hacker

doi:10.1016/0304-3835(86)90119-9

Metabolism of tiazofurin by human erythrocytes and mononuclear blood cells in vitro

John D. Roberts, William P. Tong, Jeanette N. Hartshorn, Miles P. Hacker

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In vitro studies of the uptake, metabolism, and release of tiazofurin by human red blood cells reveal extensive phosphorylation with intracellular trapping of drug predominantly as tiazofurin triphosphate. This phenomenon may explain, in part, the plasma pharmacokinetic profile of tiazofurin. Metabolism of tiazofurin to tiazofurin adenine dinucleotide, the presumed oncolytic metabolite, occurs in mononuclear blood cells but not in erythrocytes.

Original language	English (US)
Pages (from-to)	193-197
Number of pages	5
Journal	Cancer Letters
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(86)90119-9
State	Published - Aug 1986

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/0304-3835(86)90119-9

Cite this

@article{1c19e77ff20647e9a00b4e75c6fbcd54,

title = "Metabolism of tiazofurin by human erythrocytes and mononuclear blood cells in vitro",

abstract = "In vitro studies of the uptake, metabolism, and release of tiazofurin by human red blood cells reveal extensive phosphorylation with intracellular trapping of drug predominantly as tiazofurin triphosphate. This phenomenon may explain, in part, the plasma pharmacokinetic profile of tiazofurin. Metabolism of tiazofurin to tiazofurin adenine dinucleotide, the presumed oncolytic metabolite, occurs in mononuclear blood cells but not in erythrocytes.",

author = "Roberts, {John D.} and Tong, {William P.} and Hartshorn, {Jeanette N.} and Hacker, {Miles P.}",

year = "1986",

month = aug,

doi = "10.1016/0304-3835(86)90119-9",

language = "English (US)",

volume = "32",

pages = "193--197",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Metabolism of tiazofurin by human erythrocytes and mononuclear blood cells in vitro

AU - Roberts, John D.

AU - Tong, William P.

AU - Hartshorn, Jeanette N.

AU - Hacker, Miles P.

PY - 1986/8

Y1 - 1986/8

N2 - In vitro studies of the uptake, metabolism, and release of tiazofurin by human red blood cells reveal extensive phosphorylation with intracellular trapping of drug predominantly as tiazofurin triphosphate. This phenomenon may explain, in part, the plasma pharmacokinetic profile of tiazofurin. Metabolism of tiazofurin to tiazofurin adenine dinucleotide, the presumed oncolytic metabolite, occurs in mononuclear blood cells but not in erythrocytes.

AB - In vitro studies of the uptake, metabolism, and release of tiazofurin by human red blood cells reveal extensive phosphorylation with intracellular trapping of drug predominantly as tiazofurin triphosphate. This phenomenon may explain, in part, the plasma pharmacokinetic profile of tiazofurin. Metabolism of tiazofurin to tiazofurin adenine dinucleotide, the presumed oncolytic metabolite, occurs in mononuclear blood cells but not in erythrocytes.

UR - http://www.scopus.com/inward/record.url?scp=0022506152&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022506152&partnerID=8YFLogxK

U2 - 10.1016/0304-3835(86)90119-9

DO - 10.1016/0304-3835(86)90119-9

M3 - Article

C2 - 3756845

AN - SCOPUS:0022506152

SN - 0304-3835

VL - 32

SP - 193

EP - 197

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Metabolism of tiazofurin by human erythrocytes and mononuclear blood cells in vitro

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this