Metals in biology: Defining metalloproteomes

Steven M. Yannone; Sophia Hartung; Angeli L. Menon; Michael W.W. Adams; John A. Tainer

doi:10.1016/j.copbio.2011.11.005

Metals in biology: Defining metalloproteomes

Steven M. Yannone, Sophia Hartung, Angeli L. Menon, Michael W.W. Adams, John A. Tainer

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

The vital nature of metal uptake and balance in biology is evident in the highly evolved strategies to facilitate metal homeostasis in all three domains of life. Several decades of study on metals and metalloproteins have revealed numerous essential bio-metal functions. Recent advances in mass spectrometry, X-ray scattering/absorption, and proteomics have exposed a much broader usage of metals in biology than expected. Even elements such as uranium, arsenic, and lead are implicated in biological processes as part of an emerging and expansive view of bio-metals. Here we discuss opportunities and challenges for established and newer approaches to study metalloproteins with a focus on technologies that promise to rapidly expand our knowledge of metalloproteins and metal functions in biology.

Original language	English (US)
Pages (from-to)	89-95
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.copbio.2011.11.005
State	Published - Feb 2012
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/j.copbio.2011.11.005

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abstract = "The vital nature of metal uptake and balance in biology is evident in the highly evolved strategies to facilitate metal homeostasis in all three domains of life. Several decades of study on metals and metalloproteins have revealed numerous essential bio-metal functions. Recent advances in mass spectrometry, X-ray scattering/absorption, and proteomics have exposed a much broader usage of metals in biology than expected. Even elements such as uranium, arsenic, and lead are implicated in biological processes as part of an emerging and expansive view of bio-metals. Here we discuss opportunities and challenges for established and newer approaches to study metalloproteins with a focus on technologies that promise to rapidly expand our knowledge of metalloproteins and metal functions in biology.",

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AU - Hartung, Sophia

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AU - Tainer, John A.

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AB - The vital nature of metal uptake and balance in biology is evident in the highly evolved strategies to facilitate metal homeostasis in all three domains of life. Several decades of study on metals and metalloproteins have revealed numerous essential bio-metal functions. Recent advances in mass spectrometry, X-ray scattering/absorption, and proteomics have exposed a much broader usage of metals in biology than expected. Even elements such as uranium, arsenic, and lead are implicated in biological processes as part of an emerging and expansive view of bio-metals. Here we discuss opportunities and challenges for established and newer approaches to study metalloproteins with a focus on technologies that promise to rapidly expand our knowledge of metalloproteins and metal functions in biology.

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Metals in biology: Defining metalloproteomes

Abstract

ASJC Scopus subject areas

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