Abstract
Unexpected early epidural spinal metastatis in a case of osteosarcoma occurred in a patient receiving treatment with cis-diamminedichloroplatinum-II (cisplatin). The initial neurologic symptomatology manifested as paresthesias in the feet which developed 2 months after initiation of treatment (cumulative dose of cisplatin 450 mg/M2) at which stage the primary tumor demonstrated a marked response. Concurrently two small pulmonary metastases appeared. Epidural metastasis in osteosarcoma is generally considered a late complication and is usually associated with disseminated disease. This communication draws attention to changes in the metastatic pattern which may occur with the administration of seemingly effective treatment and the potential for confusing the symptomatology of epidural spinal metastasis with cisplatin neuropathy.
Original language | English (US) |
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Pages (from-to) | 165-167 |
Number of pages | 3 |
Journal | Journal of neuro-oncology |
Volume | 4 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1986 |
Keywords
- cisplatin, neuropathy
- epidural metastatic osteosarcoma
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research