Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment

Claudiu V. Cotta; Sergej Konoplev; L. Jeffrey Medeiros; Carlos E. Bueso-Ramos

doi:10.1016/j.anndiagpath.2006.04.001

Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment

Claudiu V. Cotta, Sergej Konoplev, L. Jeffrey Medeiros, Carlos E. Bueso-Ramos

Hematopathology

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

The nonhematopoietic tumors most often diagnosed in the bone marrow are metastatic. Currently, accurate diagnosis of tumor metastasis requires integration of the clinical findings; morphological features; and results of immunohistochemical stains, cytogenetics, and molecular studies. This review focuses on a practical approach to the diagnosis of metastatic tumors in the bone marrow according to current standards of practice and discusses recent advances in understanding of tumor metastasis and the interaction between tumors and the bone marrow environment.

Original language	English (US)
Pages (from-to)	169-192
Number of pages	24
Journal	Annals of Diagnostic Pathology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/j.anndiagpath.2006.04.001
State	Published - Jun 2006

Keywords

Bone marrow
Cytogenetics
Immunohistochemistry
Metastasis
Microenvironment
Molecular study

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.anndiagpath.2006.04.001

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title = "Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment",

abstract = "The nonhematopoietic tumors most often diagnosed in the bone marrow are metastatic. Currently, accurate diagnosis of tumor metastasis requires integration of the clinical findings; morphological features; and results of immunohistochemical stains, cytogenetics, and molecular studies. This review focuses on a practical approach to the diagnosis of metastatic tumors in the bone marrow according to current standards of practice and discusses recent advances in understanding of tumor metastasis and the interaction between tumors and the bone marrow environment.",

keywords = "Bone marrow, Cytogenetics, Immunohistochemistry, Metastasis, Microenvironment, Molecular study",

author = "Cotta, {Claudiu V.} and Sergej Konoplev and Medeiros, {L. Jeffrey} and Bueso-Ramos, {Carlos E.}",

year = "2006",

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T1 - Metastatic tumors in bone marrow

T2 - histopathology and advances in the biology of the tumor cells and bone marrow environment

AU - Cotta, Claudiu V.

AU - Konoplev, Sergej

AU - Medeiros, L. Jeffrey

AU - Bueso-Ramos, Carlos E.

PY - 2006/6

Y1 - 2006/6

N2 - The nonhematopoietic tumors most often diagnosed in the bone marrow are metastatic. Currently, accurate diagnosis of tumor metastasis requires integration of the clinical findings; morphological features; and results of immunohistochemical stains, cytogenetics, and molecular studies. This review focuses on a practical approach to the diagnosis of metastatic tumors in the bone marrow according to current standards of practice and discusses recent advances in understanding of tumor metastasis and the interaction between tumors and the bone marrow environment.

AB - The nonhematopoietic tumors most often diagnosed in the bone marrow are metastatic. Currently, accurate diagnosis of tumor metastasis requires integration of the clinical findings; morphological features; and results of immunohistochemical stains, cytogenetics, and molecular studies. This review focuses on a practical approach to the diagnosis of metastatic tumors in the bone marrow according to current standards of practice and discusses recent advances in understanding of tumor metastasis and the interaction between tumors and the bone marrow environment.

KW - Bone marrow

KW - Cytogenetics

KW - Immunohistochemistry

KW - Metastasis

KW - Microenvironment

KW - Molecular study

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SN - 1092-9134

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JO - Annals of Diagnostic Pathology

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Metastatic tumors in bone marrow: histopathology and advances in the biology of the tumor cells and bone marrow environment

Abstract

Keywords

ASJC Scopus subject areas

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